Publications by authors named "Anne Hummel"

Article Synopsis
  • MET amplification in EGFR-mutant non-small cell lung cancer (NSCLC) is a common resistance to EGFR inhibitors, and combining EGFR and MET inhibitors shows promise but has varied definitions of MET amplification.
  • In a study of 43 patients with MET copy number gain, those who received the combination of EGFR and MET inhibitors had an 82% clinical benefit rate and longer progression-free survival compared to those receiving MET inhibitors alone or standard of care.
  • The findings suggest that true MET amplification drives better outcomes with combination therapy, indicating a need for further research into how different types of MET copy number gain affect treatment response.
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The current flowing across a semiconductor superlattice in tilted electric and magnetic fields is known to exhibit resonant enhancement, when Landau states of neighboring wells align at certain ratios of the field strengths. We show that the ultrafast version of this effect, in which coherent electron wave packets are involved, has a profound analogy to the Fiske effect in superconductor Josephson junctions and superfluid weak links, in that the coupling of the tunneling-induced charge oscillations (magneto-Bloch versus Josephson oscillations) to another oscillator (in-plane cyclotron oscillations versus external oscillator modes) opens an elastic rectifying transport channel. We explore the superlattice effect both theoretically and experimentally, and find that the transient self-induced current can be adequately modeled if the damping of both types of coupled electron oscillations is properly taken into account.

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The ultimate efficiency of polymer light-emitting diodes is limited by the fraction of charges recombining in the molecular singlet manifold. We address the question of whether this fraction can principally exceed the fundamental limit set down by spin statistics, which requires the possibility of spin changes during exciton formation. Sensitized phosphorescence at 4-300 K enables a direct quantification of spin conversion in coulombically bound electron-hole pairs, the precursors to exciton formation.

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The coherent Hall effect denotes the transient Hall response of impulsively excited coherent charge-carrier wave packets in a solid. We report the first experimental study of this phenomenon (i) using a semiconductor superlattice in crossed electric and magnetic fields as a model for three-dimensional materials and (ii) employing a contactless optoelectronic technique to probe the transient currents. Two field regimes with distinctly different oscillatory wave packet dynamics are found, separated from each other by a transition region where all oscillations are suppressed.

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