Biomarkers.

Background: While some memory decline in old age is "normal", there are some older individuals with maintained high cognitive performance. Using a multimodal approach including neuroimaging, fitness, genetic and questionnaire data (Figure 1A), we aimed to identify factors that are related to successful cognitive aging and whether these differ between sexes.

Method: We analyzed 165 cognitively normal older adults age ≥ 60 years from an ongoing study (SFB1436) (age=71±8years, 43% female).

Developing Topics.

Background: Previous studies have examined the impact of post-traumatic stress disorder and chronic stress on the Locus Coeruleus-Noradrenergic System (LC-NA) revealing significant neurobiological alterations (Aston-Jones & Cohen, 2005; McCall et al., 2015). However, while animal studies have yielded valuable insights regarding the effects of traumatic experiences on the LC-NA system, translation to human models remains relatively underexplored.

Alzheimer's Imaging Consortium.

Background: While some memory decline in old age is "normal", there are some older individuals with maintained high cognitive performance. Using a multimodal approach including neuroimaging, fitness, genetic and questionnaire data (Fig1A), we aimed to identify factors that are related to successful cognitive aging and whether these differ between sexes.

Method: We analyzed 165 cognitively normal older adults age = 60 years from an ongoing study (SFB1436) (age = 71±8years, 43% female).

"Mickey Mousing" in the Brain: Motion-Sound Synesthesia and the Subcortical Substrate of Audio-Visual Integration.

Motion-sound synesthesia is characterized by illusory auditory sensations linked to the pattern and rhythms of motion (dubbed "Mickey Mousing" as in cinema) of visually experienced but soundless object, like an optical flow array, a ball bouncing or a horse galloping. In an MRI study with a group of three synesthetes and a group of eighteen control participants, we found structural changes in the brains of synesthetes in the subcortical multisensory areas of the superior and inferior colliculi. In addition, functional magnetic resonance imaging data showed activity in motion-sensitive regions, as well as temporal and occipital areas, and the cerebellum.