Publications by authors named "Anne Hapke"
Objectives: Subarachnoid hemorrhage (SAH) may critically impair cardiovascular, metabolic, and gastrointestinal function. Previous research has demonstrated compromised drug absorption in this group of patients. This study aimed to examine the impact of SAH on gastrointestinal function and its subsequent effect on the absorption of enterally administered drugs, using esomeprazole as a probe drug.
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- - In critically ill cardiac patients, drug absorption and metabolism can be significantly altered, particularly demonstrated through the examination of esomeprazole pharmacokinetics in those experiencing cardiogenic shock.
- - The study found that the maximum plasma concentration and overall exposure (AUC) of esomeprazole were about half in critically ill patients compared to healthy controls, and this reduced absorption persisted even a week after cardiac surgery.
- - The results suggest a need for intravenous administration of essential medications in these patients due to compromised gastrointestinal drug absorption, alongside a potential reduction in liver metabolism by the CYP3A4 enzyme post-shock.