Group intervention programs and their impact on well-being and quality-of-life for adults living with a rare or orphan disease - realist review of literature.

Purpose: Adults living with a rare or orphan diseases (ROD) experience common psychosocial difficulties that are often poorly addressed in usual care. This realist literature review aims to inform the development, evaluation and implementation of evidence based group therapy programs adapted to shared needs of patients living with various ROD.

Method: The review is based on an analysis of Context-Mechanism-Outcome configurations.