Peptide-Bound Glycative, AGE and Oxidative Modifications as Biomarkers for the Diagnosis of Alzheimer's Disease-A Feasibility Study.

The diagnosis of Alzheimer's disease (AD) relies on core cerebrospinal fluid (CSF) biomarkers, amyloid beta (Aβ) and tau. As the brain is then already damaged, researchers still strive to discover earlier biomarkers of disease onset and the progression of AD. Glycation, advanced glycation end products (AGEs) and oxidative modifications on proteins in CSF mirror the underlying biological mechanisms that contribute to early AD pathology.

Detailing the biomedical aspects of geroscience by molecular data and large-scale "deep" bioinformatics analyses.

As scientists investigated the molecular mechanisms of the biology of aging, they discovered that these are malleable and can enhance healthy longevity by intervening in the drivers of aging, which are leading to disease, dysfunction and death. These exciting observations gave birth to the field of geroscience. As the mechanisms of aging affect almost all mechanisms of life, detailed molecular mechanistic knowledge must be gained or expanded by considering and integrating as many types of data as possible, from genes and transcripts to socioenvironmental factors.

Association of subendocardial viability ratio and mortality in the elderly population: results from the CARdiovascular disease, Living and Ageing in Halle study.

Objectives: The subendocardial viability ratio (SEVR) reflects the balance of myocardial oxygen supply and demand. Low SEVR indicates a reduced subendocardial perfusion and has been shown to predict mortality in patients with kidney disease and diabetes. The aim of this study is to investigate the association of SEVR and mortality in the elderly population.

Prediction Model for Contractile Function of Circulatory Death Donor Hearts Based on Microvascular Flow Shifts During Ex Situ Hypothermic Cardioplegic Machine Perfusion.

Background Hearts procured from circulatory death donors (DCD) are predominantly maintained by machine perfusion (MP) with normothermic donor blood. Currently, DCD heart function is evaluated by lactate and visual inspection. We have shown that MP with the cardioplegic, crystalloid Custodiol-N solution is superior to blood perfusion to maintain porcine DCD hearts.

[Aging of the immune system].

With increasing age a rise in the incidence of infections, inflammatory diseases such as arteriosclerosis and tumors and simultaneously a reduction in the success of vaccinations can be observed. A dysfunctional immune system is responsible for this. The immune system can be divided into three domains.

[Biological mechanisms of aging in the cardiovascular system].

Cardiovascular diseases, which are at the end of a spectrum of degenerative processes, are one of the leading causes of death worldwide. A causal contribution to these and many other diseases is made by key biological aging mechanisms that have been summarized as the hallmarks of aging. These include accumulation of macromolecular damage, epigenetic changes, impaired proteostasis, telomere shortening, mitochondrial dysfunction, cellular senescence, inflammatory reactions, altered metabolism, impaired cellular communication and changes in the stem cell niche.

The relationship of skin autofluorescence with diastolic function and HFA-PEFF score in a general population of older people.

Background And Aims: Advanced glycation end-products accumulation in tissue as measured by Skin autofluorescence (SAF) is related to diastolic function in specific patient populations. This analysis aims at investigating this relationship in a general population of older persons.

Methods And Results: Based on data from the CARLA cohort at first follow-up, 245 subjects were analyzed and stratified according to cardiovascular risk factors (CVRF).

Sex-dependent deterioration of cardiac function and molecular alterations in age- and disease-associated RAGE overexpression.

Elevated expression of the receptor for advanced-glycation endproducts (RAGE) in cardiac tissue is well-known in the elderly, in diabetes mellitus, and after acute cardiac infarction or ischemia/reperfusion injuries. RAGE and its binding partners affect the clinical outcome of heart failure and may play an essential role in accelerating the functional decline in cardiovascular aging. Therefore, hearts of wild-type (WT) C57black6/N and cardiac-specific RAGE-overexpressing transgenic (TR) mice were analyzed for their function by ultrasound at young (4-5 months) and old (22-23 months) ages.

AGE-Rich Bread Crust Extract Boosts Oxidative Stress Interception via Stimulation of the NRF2 Pathway.

Advanced glycation end products (AGEs) result from a non-enzymatic reaction of proteins with reactive carbohydrates. Heat-processed food, such as bread, contains high amounts of AGEs. The activation of the NF-κB signaling pathway by bread crust extract (BCE) is well understood.

Relationship of Laser-Doppler-Flow and coronary perfusion and a concise update on the importance of coronary microcirculation in donor heart machine perfusion.

Background: Machine perfusion (MP) is a novel method for donor heart preservation. The coronary microvascular function is important for the transplantation outcome. However, current research on MP in heart transplantation focuses mainly on contractile function.

Carbohydrates in nutrition: friend or foe?

Fats, proteins and carbohydrates are the main energy supplies in human nutrition. The ratio of these three has often been discussed within the nutritional sciences over the years. Carbohydrates were important for our ancestors since many carbohydrate-rich foods were easily storable without cooling in comparison to protein-rich or fat-rich food, such as meat or fish.