Publications by authors named "Anne F van Rijn"
Aim: To improve the interpretation of fecal immunochemical test (FIT) results in colorectal cancer (CRC) cases from screening and referral cohorts.
Methods: In this comparative observational study, two prospective cohorts of CRC cases were compared. The first cohort was obtained from 10 322 average risk subjects invited for CRC screening with FIT, of which, only subjects with a positive FIT were referred for colonoscopy.
Inappropriate use of the faecal occult blood test in a university hospital in the Netherlands.
Eur J Gastroenterol Hepatol
November 2012
Article Synopsis
- The study aimed to investigate the adherence to guidelines regarding the use of fecal occult blood tests (FOBT) in symptomatic patients across 15 hospitals in the Netherlands.
- It found that FOBTs were ordered frequently, often for irrelevant symptoms, with 2993 tests performed in one year and varied follow-up investigations based on test results.
- The results indicate a common misuse of FOBT as a diagnostic test rather than as a screening tool, leading to confusion and potential delays in patient care.
Article Synopsis
- A study analyzed the cost-effectiveness of colorectal cancer screening strategies, comparing immunochemical fecal occult blood testing (I-FOBT) with guaiac FOBT (G-FOBT) and no screening in Dutch individuals aged 50 to 75.
- The research found that I-FOBT was the most effective, providing an average gain of 0.003 life-years and savings of €27 compared to G-FOBT, and €72 compared to no screening.
- Overall, implementing I-FOBT screening among 4.46 million Dutch individuals could save 13,400 life-years and approximately €320 million.
Article Synopsis
- A study investigated how people perceive two types of fecal occult blood tests (FOBT) for colorectal cancer screening: guaiac FOBT (g-FOBT) and immunological FOBT (i-FOBT).
- The results showed that i-FOBT was viewed more favorably, with fewer participants finding it difficult or unpleasant compared to g-FOBT.
- Additionally, participation rates were significantly higher for i-FOBT recipients (60%) than g-FOBT recipients (47%), suggesting i-FOBT is a better choice for screening programs.
Article Synopsis
- The study aimed to assess how accurately computed tomography colonography (CTC) detects colorectal neoplasia in patients who tested positive on a Fecal Occult Blood Test (FOBT).
- Participants underwent CTC followed by colonoscopy, with results showing CTC had a sensitivity of 95% for detecting carcinomas and 92% for advanced adenomas.
- The conclusion suggests that CTC, even with minimal bowel prep, shows high diagnostic accuracy similar to colonoscopy for identifying significant lesions in a FOBT positive population.
Article Synopsis
- - Delays in returning immunochemical fecal occult blood test (iFOBT) samples to the lab, especially beyond 5 days, can lead to false negatives due to degradation of hemoglobin levels in the samples.
- - A study found that after a delay of >5 days, the adenoma detection rate significantly decreased, with notable increases in false negatives among patients, particularly those with advanced adenomas and colorectal cancer.
- - The research indicates that both precursor lesions and existing colorectal cancer cases can be missed because of the hemoglobin deterioration in delayed samples, highlighting the importance of timely lab delivery for effective screening.
Article Synopsis
- A study was conducted to assess how well gastroenterologists in The Netherlands adhere to surveillance guidelines for patients with long-standing colitis.
- Out of 244 gastroenterologists surveyed, 63% responded, with 95% performing endoscopic surveillance on ulcerative colitis patients but only 27% following the recommended guidelines.
- Many gastroenterologists underperformed in taking biopsies and referring patients for colectomy in cases of dysplasia, which could reduce the effectiveness of colorectal cancer screenings.
Background & Aims: Despite poor performance, guaiac-based fecal occult blood tests (G-FOBT) are most frequently implemented for colorectal cancer screening. Immunochemical fecal occult blood tests (I-FOBT) are claimed to perform better, without randomized comparison in screening populations. Our aim was to randomly compare G-FOBT with I-FOBT in a screening population.
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