Publications by authors named "Anne Eriksson Agger"
Article Synopsis
- The study aimed to replicate inflammatory conditions of human gingiva by using human gingiva fibroblast cells cultured under specific serum starvation conditions with various concentrations of lipopolysaccharides and interleukin 1β.
- Results showed that while P. gingivalis LPS did not increase inflammation markers, E. coli LPS and IL-1β did enhance the secretion of pro-inflammatory cytokines like IL-6 and TNFα, particularly when used together.
- The combination treatment mimicked gene expression changes and cytokine profiles observed in chronic inflammation, suggesting it could serve as a useful model for studying gingival inflammation in vitro.
Surface chemistry evaluation is crucial in assessing the efficacy of chemical decontamination products for titanium implants. This study aimed to investigate the effectiveness of chemical decontamination solutions in cleaning a contaminated dental implant surface and to evaluate the potential of combining Pluronic gel with hydrogen peroxide (NuBoneClean) by evaluating pellicle disruption and re-formation on implant surfaces. In addition, ensuring safety with in vitro and human testing protocols.
View Article and Find Full Text PDFObjectives: This study aimed to identify disease-related markers in persistent apical periodontitis (PAP) biopsies and examine whether these were associated with comorbidities like rheumatoid arthritis (RA) and cardiovascular diseases (CVD).
Materials And Method: The levels of the cytokines/chemokines GM-CSF, IFN-γ, IL-2, IL-6, IL-9, IL-10, IL-13, IL-15, IL-17E/IL-25, IL-21, IL-23, IL-27, IL-28A/IFN -λ2, IL-33, MIP-3α/CCL20, and TNF-α were determined in lesions from patients with PAP (n = 20) and compared to healthy bone samples (n = 20).
Results: We identified eleven cytokines to be differently expressed, and among them, IL-2, IL-6, IL-17E, IL-21, and IL-27 appeared to drive the discrepancy between the disease and healthy groups.
Background: Irisin is expressed in human periodontal ligament (hPDL), and its administration enhances growth, migration and matrix deposition in hPDL cells cultured in monolayers in vitro.
Objectives: To identify whether irisin affects the gene expression patterns directing the morphology, mechanical properties, extracellular matrix (ECM) formation, osteogenic activity and angiogenic potential in hPDL cell spheroids cultured in 3D.
Materials And Methods: Spheroids of primary human hPDL cells were generated in a rotational 3D culture system and treated with or without irisin.