Publications by authors named "Anne E Senters"
Previous drug selection experiments resulted in the isolation of a human cytomegalovirus (CMV) UL97 phosphotransferase mutant resistant to the benzimidazole compound maribavir (1263W94), reflecting the anti-UL97 effect of this drug. Three other CMV strains were plaque purified during these experiments. These strains showed lower-grade resistance to maribavir than the UL97 mutant.
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- Recent analyses using large molecular data sets have helped clarify phylogenetic relationships among various angiosperm lineages, yet the core eudicots—like Berberidopsidales and asterids—remain poorly understood with only three genes tested.
- A new study included 26S rDNA sequences in addition to three genes for a more comprehensive analysis of 201 eudicot species, revealing moderate support for Gunnerales as a sister group to all other core eudicots.
- The research suggests that the evolution of floral structures in core eudicots likely transitioned from a dimerous perianth (common in early-diverging eudicots) to the more common pentamerous structure after the divergence of
Most ganciclovir (GCV)-resistant cytomegalovirus (CMV) isolates contain UL97 gene mutations at codon 460 or 520 or between codons 590 and 607, where an increasing variety of mutations have been detected, including deletions. To determine their phenotypic effect, 9 UL97 mutations not previously studied were transferred to drug-sensitive laboratory CMV strains that contained unique restriction sites developed for this purpose. Deletion of the entire codon range 591-607 conferred a 6-fold increase in GCV resistance, with little effect on viral replication.
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