Primary Hyperparathyroidism induces Erythropoietin resistance through FGF23.

Introduction: Primary hyperparathyroidism (PHPT) often causes hypercalcemia and complications requiring parathyroidectomy (PTX). Anemia affects 15-50% of PHPT patients, but its mechanisms remain unclear. While parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) contribute to anemia in secondary hyperparathyroidism (SHPT) through erythropoietin (EPO) resistance and bone marrow fibrosis, their roles in PHPT are less defined.

Impact of Different CKD Definitions on Long-Term Renal Function and Mortality in a Population-Based Cohort Study.

Introduction: The adoption of age or individualized body surface area (i-BSA) estimated glomerular filtration rate (eGFR) thresholds could influence the prevalence and prognosis of chronic kidney disease (CKD). This longitudinal study with up to 15 years of follow-up in the general population, compares different eGFR thresholds for CKD definition: standard, corrected to i-BSA, and age-stratified. For each, we assessed the prevalence of CKD and the combined impact on rapid renal function decline (RRFD) and mortality.

Outcomes of incident patients treated with incremental haemodialysis as compared with standard haemodialysis and peritoneal dialysis.

Background: Residual kidney function is considered better preserved with incremental haemodialysis (I-HD) or peritoneal dialysis (PD) as compared with conventional thrice-weekly HD (TW-HD) and is associated with improved survival. We aimed to describe outcomes of patients initiating dialysis with I-HD, TW-HD or PD.

Methods: We conducted a retrospective analysis of a prospectively assembled cohort in a single university centre including all adults initiating dialysis from January 2013 to December 2020.