Publications by authors named "Anne Drolet"
Article Synopsis
- Traumatic Brain Injuries (TBIs) can vary in severity and may lead to increased intracranial pressure (ICP), which presents with key physical signs and requires monitoring through the Glasgow Coma Scale (GCS) and cranial CT scans.
- A case is presented of a 6-year-old boy who sustained a head injury from a fall, showing initial stability with a GCS score of 15, but later developed symptoms of increased ICP, confirmed by imaging as a subdural hematoma with a midline shift.
- Although the GCS score remained high, ongoing monitoring and treatment were essential for this patient due to the potential complications of TBIs, emphasizing the need for careful assessment beyond initial scores.
Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA.
Objective: To identify additional AAA risk loci using data from all available genome-wide association studies.
Knowledge of the genetic basis of the type 2 diabetes (T2D)-related quantitative traits fasting glucose (FG) and insulin (FI) in African ancestry (AA) individuals has been limited. In non-diabetic subjects of AA (n = 20,209) and European ancestry (EA; n = 57,292), we performed trans-ethnic (AA+EA) fine-mapping of 54 established EA FG or FI loci with detailed functional annotation, assessed their relevance in AA individuals, and sought previously undescribed loci through trans-ethnic (AA+EA) meta-analysis. We narrowed credible sets of variants driving association signals for 22/54 EA-associated loci; 18/22 credible sets overlapped with active islet-specific enhancers or transcription factor (TF) binding sites, and 21/22 contained at least one TF motif.
View Article and Find Full Text PDFBackground: Prolonged bed rest in hospitalized patients leads to deconditioning, impaired mobility, and the potential for longer hospital stays.
Objective: The purpose of this study was to determine the effectiveness of a nurse-driven mobility protocol to increase the percentage of patients ambulating during the first 72 hours of their hospital stay.
Design: A quasi-experimental design was used before and after intervention in a 16-bed adult medical/surgical intensive care unit (ICU) and a 26-bed adult intermediate care unit (IMCU) at a large community hospital.