Publications by authors named "Anne Coste"
Article Synopsis
- * This study analyzed cases of C bantiana infections in France and its territories, involving patients who were diagnosed through a comprehensive surveillance program, focusing on survival rates and the presence of central nervous system (CNS) involvement.
- * Out of 23 patients identified from 2002 to 2022, 65% had CNS involvement, with a notable increase in cases reported in 2022, indicating a possible correlation with environmental factors like rising temperatures.
Objective: Acute graft pyelonephritis (AGPN) is the most frequent infectious complication in kidney transplant recipients (KTR). The treatment of acute community-acquired (CA) pyelonephritis is based on third-generation cephalosporins (3GC) and fluoroquinolones. Cefepime or a piperacillin-tazobactam combination are more often used in healthcare-associated (HCA) infections.
View Article and Find Full Text PDFBackground: Pulmonary mucormycosis (PM) is a life-threatening invasive mold infection. Diagnosis of mucormycosis is challenging and often delayed, resulting in higher mortality.
Research Question: Are the disease presentation of PM and contribution of diagnosis tools influenced by the patient's underlying condition?
Study Design And Methods: All PM cases from six French teaching hospitals between 2008 and 2019 were retrospectively reviewed.
Mucormycosis is a rare but life-threatening fungal infection due to molds of the order Mucorales. The incidence has been increasing over recent decades. Worldwide, pulmonary mucormycosis (PM) presents in the lungs, which are the third main location for the infection after the rhino-orbito-cerebral (ROC) areas and the skin.
View Article and Find Full Text PDFFrench guidelines recommend reaching an amikacin concentration of ≥8 × MIC 1 h after beginning infusion (C), with MIC = 8 mg/L for probabilistic therapy. We aimed to elaborate a nomogram guiding clinicians in choosing the right first amikacin dose for ICU patients in septic shock. A total of 138 patients with 407 observations were prospectively recruited.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess the occurrence of the abscopal response (AR) in metastatic melanoma patients undergoing palliative radiotherapy, focusing on those receiving specific conditions of systemic treatments.
- Out of 118 patients analyzed, 15 (12.7%) exhibited an AR, showing significantly improved overall survival and progression-free survival compared to those without an AR.
- The findings suggest that AR is a rare but important indicator of better prognosis and may be enhanced by concurrent treatments like immunotherapy and infections during radiotherapy.
Model-informed precision dosing is being increasingly used to improve therapeutic drug monitoring. To meet this need, several tools have been developed, but open-source software remains uncommon. Posologyr is a free and open-source R package developed to enable Bayesian individual parameter estimation and dose individualization.
View Article and Find Full Text PDFObjectives: To determine the frequency and prognosis of invasive pulmonary aspergillosis in critically ill patients with severe influenza pneumonia.
Design: Retrospective multicenter cohort study.
Setting: Five French ICUs.
Objectives: Prosthetic vascular graft infection (PVGI) is a very severe disease. We aimed to determine the factors associated with treatment failure.
Methods: Patients admitted to two University Hospitals with PVGI were included in this retrospective study.