Poly(trimethylene carbonate)-based composite materials for reconstruction of critical-sized cranial bone defects in sheep.

Purpose: The use of ceramic materials in repair of bone defects is limited to non-load-bearing sites. We tested poly(trimethylene carbonate) (PTMC) combined with β-tricalcium phosphate or biphasic calcium phosphate particles for reconstruction of cranial defects.

Materials And Methods: PTMC-calcium phosphate composite matrices were implanted in cranial defects in sheep for 3 and 9 months.

A Retrospective Review of Reconstructive Options and Outcomes of 202 Cases Large Facial Mohs Micrographic Surgical Defects, Based on the Aesthetic Unit Involved.

Background: For optimal treatment of facial defects following Mohs micrographic surgery (MMS), the aesthetic unit principles should be applied. Often multiple staged procedures and revisions are necessary.

Objective: To analyze the reconstructive options and outcomes for complex facial defects per aesthetic unit.

Fracture of the genial tubercles of the mandible: case report and review of the literature.

Fracture of the genial tubercles is a rare occurrence and can occur as a solitary fracture or an associated fracture of the mandible. A solitary fracture seems to be associated with severe atrophy of the mandible. A report of a case of fractured genial tubercles in an 80-year-old edentulous female patient is described and a review of the literature is presented.

Composite materials based on poly(trimethylene carbonate) and β-tricalcium phosphate for orbital floor and wall reconstruction.

Poly(trimethylene carbonate) and β-tricalcium phosphate (PTMC/β-TCP) composite materials were prepared by coprecipitation and compression molding. The effect of different amounts of the ceramic component (15 and 30 vol %) on the properties was investigated. The effect of lamination with minimal amounts of poly(D,L-lactide) (PDLLA) was assessed as well.

Tracer-cocktail injections for combined pre- and intraoperative multimodal imaging of lymph nodes in a spontaneous mouse prostate tumor model.

To improve surgical guidance toward prostate draining lymph nodes, we investigate the potential of intraoperative fluorescence imaging and combined pre- and intraoperative multimodality imaging approaches. Transgenic adenocarcinoma mouse prostate mice with spontaneous prostate tumors are injected intratumorally with: 1. a cocktail of patent blue (Pb) and indocyanine green (ICG); 2.

Questioning the value of (99m)Tc-HYNIC-annexin V based response monitoring after docetaxel treatment in a mouse model for hereditary breast cancer.

Annexin V imaging is suggested to provide a good indication of cancer treatment efficacy. To study the accuracy of (99m)Tc-AnxV imaging, we monitored chemo-sensitive and chemo-resistant tumors in a mouse breast cancer model after treatment with docetaxel. Sensitive tumors showed a slight peak in (99m)Tc-AnxV uptake one day post-treatment, while uptake in resistant tumors remained constant.

A self-assembled multimodal complex for combined pre- and intraoperative imaging of the sentinel lymph node.

Specific removal of the sentinel lymph node (SLN) during breast cancer surgery presents physicians with the opportunity to detect early metastatic disease. To increase the accuracy of intraoperative SLN detection, new methods with higher sensitivity and specificity are required. We have quantitatively compared conventional preoperative lymphoscintigraphy with albumin radiocolloids ((99m)Tc-NanoColl) with optical intraoperative guidance using the near infrared dye indocyanine green (ICG) in an orthotopic mouse model for metastatic breast cancer.

Heterochrony in limb evolution: developmental mechanisms and natural selection.

The tetrapod limb provides several examples of heterochrony-changes in the timing of developmental events. These include species differences in the sequence of skeletal chondrogenesis, in gene transcription in the developing limbs, and in the relative time at which forelimb and hind limb buds develop. Here, we examine (i) phylogenetic trends in limb heterochrony; (ii) changes in developmental mechanisms that may lead to heterochrony; and (iii) the possible role that heterochrony plays in generating adaptive traits.