Publications by authors named "Anne C Siler"
Article Synopsis
- * Studies showed that both medications can reduce pain more effectively than placebo, with pregabalin showing a response rate of 38-50% and gabapentin at 51%, but a significant number of patients may lose responsiveness over time.
- * Adverse effects were similar between the drugs and placebo, and without direct comparisons, it’s unclear which drug is superior; more research is needed to explore long-term impacts and the overall effectiveness of these medications for
Exposure to Mycobacterium tuberculosis can result in lifelong but asymptomatic infection in most individuals. Although CD8(+) T cells are elicited at high frequencies over the course of infection in both humans and mice, how phagosomal M. tuberculosis Ags are processed and presented by MHC class I molecules is poorly understood.
View Article and Find Full Text PDFMycobacterium tuberculosis (Mtb) resides in a long-lived phagosomal compartment that resists maturation. The manner by which Mtb antigens are processed and presented on MHC Class I molecules is poorly understood. Using human dendritic cells and IFN-gamma release by CD8(+) T cell clones, we examined the processing and presentation pathway for two Mtb-derived antigens, each presented by a distinct HLA-I allele (HLA-Ia versus HLA-Ib).
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