In vitro elution and antibacterial activity of clindamycin, amikacin, and vancomycin from R-gel polymer.

Objective: To characterize the in vitro elution and bioactivity of 2 formulations of antibiotics in a novel, dissolvable, cross-linked dextran polymer matrix: Formulation 1-amikacin and clindamycin (AC); Formulation 2-amikacin, clindamycin, and vancomycin (ACV).

Study Design: Prospective, in vitro, experimental study.

Methods: Aliquots of the antibiotic impregnated polymer were incubated in PBS buffer for 10 days.

Investigation of Keyes skin biopsy instrument for intestinal biopsy versus a standard biopsy technique.

A prospective, clinical trial was conducted using 12 dogs that were presented for intestinal biopsy. Comparisons were made between paired jejunal biopsies collected using a Keyes biopsy punch and a standard scissor excisional technique. There were no differences in speed of collection, diagnostic value of specimens, complication rates, or sample quality.

Chronic diaphragmatic hernia in 34 dogs and 16 cats.

Medical records of 34 dogs and 16 cats undergoing surgical repair of diaphragmatic hernia of >2 weeks' duration were reviewed, and long-term follow-up information was obtained. The most common clinical signs were dyspnea and vomiting; however, many of the animals were presented for nonspecific signs such as anorexia, lethargy, and weight loss. Thoracic radiographs revealed evidence of diaphragmatic hernia in only 66% of the animals, and additional imaging tests were often needed to confirm the diagnosis.