Emotion awareness and cognitive behavioural therapy in young people with autism spectrum disorder.

Young people with autism spectrum disorder experience high levels of emotional problems, including anxiety and depression. Adapted cognitive behavioural therapy is recommended for such difficulties. However, no evidence suggests whether emotion awareness is important in treatment outcome for young people on the autism spectrum.

An audit of growth hormone replacement for GH-deficient adults in Scotland.

Objective: Guidelines on the clinical use of growth hormone therapy in adults were issued by the UK National Institute for Clinical Excellence (NICE) in August 2003. We conducted a retrospective clinical audit on the use of growth hormone (GH) in Scotland to evaluate the use of these guidelines and their impact on clinical practice. The audit had two phases.

Classification and nomenclature of all human homeobox genes.

Background: The homeobox genes are a large and diverse group of genes, many of which play important roles in the embryonic development of animals. Increasingly, homeobox genes are being compared between genomes in an attempt to understand the evolution of animal development. Despite their importance, the full diversity of human homeobox genes has not previously been described.

Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line.

The homeobox genes comprise a large gene superfamily characterised by a conserved DNA motif encoding the homeodomain. Most homeodomain proteins function as transcription factors, and many have important roles in embryonic development and cell differentiation. Here we describe, annotate and name four novel homeobox genes in the human genome: ARGFX, DPRX, TPRX1 and DUXA.

Eleven daughters of NANOG.

Nanog is a recently discovered ANTP class homeobox gene. Mouse Nanog is expressed in the inner cell mass and in embryonic stem cells and has roles in self-renewal and maintenance of pluripotency. Here we describe the location, genomic organization, and relative ages of all human NANOG pseudogenes, comprising ten processed pseudogenes and one tandem duplicate.

Targeting the health care needs of young offenders.

Youth offending teams offer a multiagency, holistic approach to the complex difficulties presented by young people who commit crime. This article describes the work of such teams and, in particular, the role of health practitioners in them. It also examines the structural support and organisation necessary to develop effective working practices in such a diverse team and considers other service developments that would be useful for youth offenders with mental health problems.