Danish national guideline for the treatment of infection and use of faecal microbiota transplantation (FMT).

This Danish national guideline describes the treatment of adult patients with Clostridioides (formerly Clostridium) difficile (CD) infection and the use of faecal microbiota transplantation (FMT). It suggests minimum standard for implementing an FMT service. Four scientific societies appointed members for a working group which conducted a systematic literature review and agreed on the text and recommendations.

Randomised clinical trial: a 12-strain bacterial mixture versus faecal microbiota transplantation versus vancomycin for recurrent Clostridioides difficile infections.

Background: A defined bacterial mixture could be a safer alternative to faecal microbiota transplantation (FMT).

Aims: To compare the efficacy of a 12-strain mixture termed rectal bacteriotherapy with either FMT or vancomycin for recurrent Clostridioides difficile infection (CDI) in an open-label 3-arm randomised controlled trial.

Methods: We screened all individuals positive for C difficile from May 2017 to March 2019.