Perturbations in Microbial Communities at Hydrothermal Vents of Panarea Island (Aeolian Islands, Italy).

Marine hydrothermal ecosystems represent extreme environments connected to submarine volcanic areas characterized by vents, having high temperatures and particular chemical compositions. The hydrothermal marine system of Panarea, located in one of the seven small islands belonging to the Aeolian Archipelago (southern Tyrrhenian Sea), is characterized by a range of vents exhibiting diverse physical and chemical conditions. We aimed to analyze the microbial community of a peculiar hot spring belonging to the Panarea hydrothermal field, known as "Black Point" (BP), in two separate sampling expeditions (May and August).

Novel Antibacterial 4-Piperazinylquinoline Hybrid Derivatives Against : Design, Synthesis, and In Vitro and In Silico Insights.

Molecular hybridization, which consists of the combination of two or more pharmacophores into a single molecule, is an innovative approach in drug design to afford new chemical entities with enhanced biological activity. In the present study, this strategy was pursued to develop a new series of 6,7-dimethoxy-4-piperazinylquinoline-3-carbonitrile derivatives (-) with potential antibiotic activity by combining the quinoline, the piperazinyl, and the benzoylamino moieties, three recurrent frameworks in antimicrobial research. Initial in silico evaluations were conducted on the designed compounds, highlighting favorable ADMET and drug-likeness properties, which were synthesized through a multistep strategy, isolated, and fully characterized.

Validity of the Italian Code of Ethics for everyday nursing practice.

Background:: The research question for this study was as follows: Is the Code of Ethics for Nurses in Italy (Code) a valid or useful decision-making instrument for nurses faced with ethical problems in their daily clinical practice?

Method:: Focus groups were conducted to analyze specific ethical problems through 11 case studies. The analysis was conducted using sections of the Code as well as other relevant documents. Each focus group had a specific theme and nurses participated freely in the discussions according to their respective clinical competencies.