Publications by authors named "Annamaria Cattelan"
Almost 25 years have now passed since the first identification of (). It can cause infections both in immunocompetent and immunocompromised hosts. However, it has been rarely described as an aetiology of infectious endocarditis.
View Article and Find Full Text PDFObjective: Sleep disorders (SD) are prevalent in people with HIV (PWH), but poorly addressed in HIV care. We evaluated the effectiveness of a multidimensional program for SD in an outpatient HIV clinic.
Methods: Interventional study in 175 PWH on ART suffering from insomnia.
Background: Molnupiravir (MOL) and nirmatrelvir/ritonavir (NIR) decreased mortality and hospital admissions in high-risk patients with mild to moderate COVID-19. Nevertheless, there is a lack of data about the pharmacoeconomic impact of these antivirals in the Omicron era. We conducted a pharmacoeconomic analysis assessing the medical costs of the use of these antivirals compared to those occurred in people who refused the treatment.
View Article and Find Full Text PDFBackground: Screening programmes for the detection of patients with hepatitis C virus (HCV) and positive viral load have been developed in many countries to achieve the World Health Organization's goal of HCV elimination by 2030. In Italy, a phased screening programme starting with individuals born between 1969 and 1989 has been implemented.
Aim: To assess the prevalence of patients with positive viraemia identified through a universal screening campaign conducted among hospitalised patients at our centre during the calendar year 2022.
Background: The COVID-19 pandemic posed significant challenges worldwide, with SARS-CoV-2 vaccines critical in reducing morbidity and mortality. This study evaluates the immunogenicity and antibody persistence of the BNT162b2 vaccine in people living with HIV (PLWH).
Methods: We monitored anti-SARS-CoV-2 Spike IgG concentration in a cohort of PLWH at five time points (T0-T4) using chemiluminescent microparticle immunoassays (CMIAs) at the baselined both during and after vaccination.
The literature on COVID-19 continues to increase daily. Cognitive sequelae associated with COVID-19 infection still draw the attention of the scientific community given the lack of consensus about their existence, etiology, characterization and reversibility. The aim of this study is to provide a neuropsychological identikit for younger (<65 years) and older (≥65 years) individuals diagnosed with COVID-19 infection, at baseline and after 3 and 6 months.
View Article and Find Full Text PDFBackground: Even after the development of vaccines, SARS-CoV-2 continues to cause severe pneumonia all over the world. Consequently, in order to improve the management of patients and optimize the use of resources, predictors of disease severity and lung complications after COVID-19 pneumonia are urgently needed. Blood cell count is an easily available and reproducible biomarker.
View Article and Find Full Text PDFThis study investigates the prevalence and patterns of transmitted drug resistance mutations (TDRMs) and HIV-1 subtypes among antiretroviral therapy (ART) naïve individuals in Veneto, Italy, from 2017 to 2024. This research aims to understand the dynamic landscape of TDRMs and HIV-1 genetic diversity to inform treatment strategies effectively. We included all adult ART-naïve people with HIV (PWH) from seven infectious disease units in Veneto, Italy.
View Article and Find Full Text PDFBackground: Kaposi Sarcoma (KS) has been historically associated with HIV, especially in people with advanced immunosuppression. Its prevalence decreased over time, but management remains difficult especially when the diagnosis is late and there is a visceral involvement. Bone localization, and particularly the vertebral one, is rare.
View Article and Find Full Text PDFArticle Synopsis
- - Cefiderocol, a new antibiotic, is effective against carbapenem-resistant Gram-negative bacteria but lacks real-world usage data concerning therapy types and patient demographics.
- - A study of 200 cases found that cefiderocol was primarily used as targeted therapy (72.5%) rather than empirical (27.5%) and was administered equally as monotherapy (50.5%) and in combination (49.5%).
- - The findings highlight that specific patient histories, like previous infections and conditions, influence the choice between monotherapy and combination therapy, emphasizing the need for better guidelines and further studies on treatment efficacy.
Objectives: Advancements in Artificial Intelligence(AI) have made platforms like ChatGPT increasingly relevant in medicine. This study assesses ChatGPT's utility in addressing bacterial infection-related questions and antibiogram-based clinical cases.
Methods: This study involved a collaborative effort involving infectious disease (ID) specialists and residents.
Objective: Binge eating is a mental health disorder related to weight gain, whose prevalence/correlation with weight excess in people with HIV (PWH) have been scarcely investigated.Design: A cross-sectional study of PWH who underwent the validated Binge Eating Scale (BES) questionnaire.
Methods: We included adult PWH during routine visits from October 2022 to February 2023.
Article Synopsis
- Injectable cabotegravir/rilpivirine (ICAB/RPV) has recently become available for HIV treatment, and this study aimed to evaluate its impact on sleep disturbances in patients who switched to this therapy.
- A total of 46 individuals participated, and they were assessed for sleep quality before and 12 weeks after starting ICAB/RPV using various sleep questionnaires; the demographic data and health records were also analyzed.
- Results showed no significant changes in sleep disturbance scores, although 37% reported feeling their sleep quality improved, indicating that switching to ICAB/RPV might have minimal negative effects on sleep despite previous concerns.
Article Synopsis
- Cardiometabolic health is critical for women with HIV, prompting an analysis of how well they meet targets for hypertension, dyslipidemia, and diabetes in a specific cohort.
- The study included 292 women, revealing that while a majority had a low cardiovascular risk, migrant women showed poorer outcomes in achieving hypertension and lipid targets compared to Italian women.
- Findings suggest that current treatment approaches are inadequate, highlighting a need for stronger drug interventions, improved adherence to treatment, and lifestyle changes for better health outcomes, particularly for migrant women with HIV.
Background: Infections are one of the most common causes of death after lung transplant (LT). However, the benefit of 'targeted' prophylaxis in LT recipients pre-colonized by Gram-negative (GN) bacteria is still unclear.
Methods: All consecutive bilateral LT recipients admitted to the Intensive Care Unit of the University Hospital of Padua (February 2016-2023) were retrospectively screened.
Article Synopsis
- Kaposi's sarcoma (KS) is a rare tumor with four clinical forms, diagnosed through histopathological and immunohistochemical analyses, and treated using a mix of local and systemic methods.
- A retrospective study analyzed 86 KS patients treated over 29 years, showing that most were male and had the classical variant, with surgery and chemotherapy being the common treatments.
- The study found a persistent treatment response in about 65% of patients, a 22% relapse rate, and an overall survival rate of 90% to 70% over 2 to 10 years, emphasizing the need for a multidisciplinary approach to manage the disease effectively.
Fungal infections (FIs) are one of the leading causes of morbidity and mortality within the first year of lung transplant (LT) in LT recipients (LTRs). Their prompt identification and treatment are crucial for a favorable LTR outcome. The objectives of our study were to assess (i) the FI incidence and colonization during the first year after a bilateral LT, (ii) the risk factors associated with FI and colonization, and (iii) the differences in fungal incidence according to the different prophylactic strategies.
View Article and Find Full Text PDFPeople aging with 4 antiretroviral class resistant HIV are a very challenging population. It is difficult to build up a fully suppressive regimen, and the high prevalence of comorbidities and polypharmacy may cause drug-drug interactions and put adherence at risk. We herein present the case of an 80-year-old man, participating in the PRESTIGIO registry, asking for a reduction in his antiretroviral burden while on polypharmacy for his comorbidities.
View Article and Find Full Text PDFBackground And Aims: An acute depletion of circulating haematopoietic stem/progenitor cells (HSPCs) occurs during COVID-19, especially among patients with a poorer disease course. We herein examined whether HSPCs levels at hospital admission for COVID-19 predict 1-year mortality and the long-COVID syndrome.
Materials And Methods: Patients hospitalized for COVID-19 in an infectious disease ward were consecutively enrolled.
Article Synopsis
- * Patients with a history of trauma showed significantly worse psychological symptoms, particularly in depression, anxiety, and obsessive-compulsive issues, compared to those without trauma.
- * The findings emphasize the need to consider trauma in the psychological care of post-COVID patients to improve intervention strategies.
Article Synopsis
- Clinical trials showed that dolutegravir and lamivudine (DTG/3TC) are effective and safe for people living with HIV, but there’s a lack of long-term data for individuals aged 65 and older.
- A study involving 112 participants aged 65 and above found that most had multimorbidity, and after switching to DTG/3TC, there were no significant changes in health parameters over a 6-year follow-up.
- The study concluded that DTG/3TC is safe and effective for older adults with HIV, maintaining a high rate of undetectable viral loads and a low rate of treatment discontinuations due to side effects or virological failure.*
COVID-19-related acute respiratory distress syndrome (CARDS) is associated with high mortality rates. We still have limited knowledge of the complex alterations developing in the lung microenvironment. The goal of the present study was to comprehensively analyze the cellular components, inflammatory signature, and respiratory pathogens in bronchoalveolar lavage (BAL) of CARDS patients (16) in comparison to those of other invasively mechanically ventilated patients (24).
View Article and Find Full Text PDFBackground: A large increase in multi-drug-resistant , especially carbapenem-resistant strains, occurred during the first two years of the COVID-19 pandemic, posing important challenges in its treatment. Cefiderocol appeared to be a good option for the treatment of Carbapenem-resistant (CR-Ab), but to date, the guidelines and evidence available are conflicting.
Methods: We retrospectively included a group of patients with CR-Ab infections (treated with colistin- or cefiderocol-based regimens) at Padua University Hospital (August 2020-July 2022) and assessed predictors of 30-day mortality, and differences in microbiological and clinical treatment.