Publications by authors named "Annalisa Sammarco"
Article Synopsis
- The study explores the gap between expected and actual spending on orphan drugs in Italy, focusing on financial aspects during the pricing and reimbursement negotiations.
- The analysis involved 52 orphan drugs authorized by the European Medicines Agency and revealed that actual spending was generally 7.6% lower than anticipated after negotiations, particularly for innovative drugs.
- Payment-by-result agreements were found to be a significant factor affecting the differences in expected spending before and after negotiations.
Objective: The main objective of this study was to explore the extent to which the incremental cost-effectiveness ratio (ICER), alongside other factors, predicts the final outcome of medicine price negotiation in Italy. The second objective was to depict the mean ICER of medicines obtained after negotiation.
Methods: Data were extracted from company dossiers submitted to the Italian Medicines Agency (AIFA) from October 2016 to January 2021 and AIFA's internal database.
Quality of health economic evaluations submitted to the Italian Medicines Agency: current state and future actions.
Int J Technol Assess Health Care
December 2020
Objectives: The purpose of this study was to evaluate the current state of health economic evaluations (HEEs) submitted by pharmaceutical companies to the Italian Medicines Agency (AIFA) as part of their pricing and reimbursement (P&R) dossiers, and to explore potential future actions in order to enhance their quality.
Methods: All company dossiers submitted from October 2016 to December 2018 were reviewed to select those containing pharmacoeconomic studies. The general characteristics of HEEs were described and their quality assessed based on a checklist adapted from Philips et al.
Background: Available scientific literature about open cholecystectomy (OC) and laparoscopic cholecystectomy (LC) does not show univocal results in terms of postoperative pulmonary function. A meta-analysis was carried out to evaluate the postoperative pulmonary function after OC and LC focusing on the Tiffenau index.
Methods: Electronic databases were consulted (Cochrane Library, Embase and Pubmed).