Publications by authors named "Annalisa Crisetti"
Article Synopsis
- Hyperkalemia is a common electrolyte imbalance, impacting around 7.3% of patients with hypertension, often due to medications or chronic kidney disease.
- A small percentage (0.04%) of these patients had familial hyperkalemic hypertension (FHH), with higher prevalence in those with unexplained hyperkalemia.
- Hyperkalemia is linked to increased cardiovascular risks, emphasizing the need for early diagnosis and tailored treatment strategies for effective management.
Article Synopsis
- Acute hepatic porphyrias (AHPs) are rare genetic disorders that affect heme production, and new therapies are being developed to treat them.
- Givosiran, an RNA interference treatment, has been approved for AHP patients over 12 years old after successful phase III trials.
- A recent case series from Italy shows that givosiran is well-tolerated in the long term and reduces attack frequency, while also improving patients' quality of life, pain, and fatigue.
Patients suffering from different forms of acute hepatic porphyria present a high risk of primary liver cancer, specifically hepatocellular carcinoma and cholangiocarcinoma, determined by the activity of the disease even though an exact mechanism of carcinogenesis has not been recognized yet. Here, we present the clinical case of a 72-year-old woman who, approximately 29 years after the diagnosis of acute intermittent porphyria, presented with intrahepatic cholangiocarcinoma with a histological diagnosis of adenocarcinoma starting from the biliary-pancreatic ducts, which was diagnosed during the clinical and anatomopathological evaluation of a pathological fracture of the femur.
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- The study analyzed the effectiveness of hydroxychloroquine (HCQ) in treating COVID-19 by observing 4,396 patients hospitalized in Italy from February to May 2020, revealing mixed results from previous research.
- Two patient clusters were identified: a younger, healthier group at lower risk of death and an older, sicker group at higher risk, highlighting differing impacts of HCQ on these populations.
- HCQ appeared to significantly reduce mortality risk in the lower risk cluster, suggesting that it may be more beneficial for patients with fewer comorbidities, potentially clarifying debates around its efficacy in COVID-19 treatment.
Common cardiovascular risk factors and in-hospital mortality in 3,894 patients with COVID-19: survival analysis and machine learning-based findings from the multicentre Italian CORIST Study.
Augusto Di Castelnuovo Marialaura Bonaccio Simona Costanzo Alessandro Gialluisi Andrea Antinori Annalisa Crisetti
Nutr Metab Cardiovasc Dis
October 2020
Article Synopsis
- A study investigated factors contributing to in-hospital death among COVID-19 patients in Italy, analyzing data from 3,894 hospitalized individuals from February to May 2020.
- Key findings showed that impaired renal function, high levels of C-reactive protein, and older age were significant predictors of mortality, with the highest death rates found in Northern Italy (15.6%) compared to Central/Southern regions (6.4%).
- The results indicated that factors like obesity, tobacco use, and cardiovascular conditions did not correlate with mortality risk, emphasizing the importance of renal health and inflammation in COVID-19 outcomes.