Publications by authors named "Annaji Venkata Nagendra Mohan"
Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors.
Cheng Hua Jin Maddeboina Krishnaiah Domalapally Sreenu Vura Bala Subrahmanyam Kota Sudhakar Rao Annaji Venkata Nagendra Mohan
Bioorg Med Chem Lett
October 2011
Article Synopsis
- A range of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazoles has been synthesized and tested for their ability to inhibit the ALK5 enzyme.
- Compound 14n demonstrated strong inhibitory effectiveness with an IC(50) value of 0.57 nM, making it a potent candidate.
- Additionally, it achieved 94% inhibition in a luciferase reporter assay in specific cell lines, indicating high potential for further research and development.
Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors.
Cheng Hua Jin Domalapally Sreenu Maddeboina Krishnaiah Vura Bala Subrahmanyam Kota Sudhakar Rao Annaji Venkata Nagendra Mohan
Eur J Med Chem
September 2011
Article Synopsis
- A series of novel compounds, specifically 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles, were synthesized and tested for their ability to inhibit ALK5 activity.
- The compound 2-[3-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-pyrazol-1-yl]-N-phenylethanethioamide (18a) demonstrated a strong inhibitory effect, with an IC(50) value of 0.013 μM.
- Additionally, it achieved 80% inhibition at a concentration of 0.1 μM in
A new class of bis heterocycles, oxazolyl/thiazolyl selenadiazoles, thiadiazoles and diazaphospholes were prepared from phenacylsulfonylacetic acid methyl ester and tested for their antimicrobial and antioxidant properties.
View Article and Find Full Text PDFNovel sulfone linked bis heterocycles containing two different heterocyclic rings viz., pyrazoline in combination with thiadiazole, oxadiazole and triazole were synthesized and studied their antimicrobial activity.
View Article and Find Full Text PDFA new class of pyrimidinetriones, thioxopyrimidinediones, pyrazolidinediones and isoxazolidinediones were prepared from (E)-1,4-diarylbut-2-ene-1,4-diones. All the new compounds synthesized were screened for antimicrobial activity.
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