Publications by authors named "Annada Joshi"
Acta Neuropathol Commun
May 2020
Article Synopsis
- * MYC is an oncogene that stimulates the expression of miR-193a, which is absent in Group 3 tumors due to promoter hypermethylation; restoring miR-193a in these cells inhibits tumor growth and increases sensitivity to radiation.
- * MiR-193a disrupts MYC signaling by downregulating its partners and leads to widespread gene expression repression, suggesting it could be a valuable therapeutic target for treating aggressive cancers driven by MY
