Publications by authors named "Annachiara Rossi"
The new diiron complexes [FeCp(CO)(L)(μ-CO){μ-CN(Me)(Cy)}]CFSO (L = pyridine, 3a; 4-aminopyridine, 3b; 4-dimethylaminopyridine, 3c; 4-trifluoromethylpyridine, 3d; nicotinic acid, 4; Cp = η-CH, Cy = CH = cyclohexyl) were synthesized in moderate to high yields using two distinct synthetic routes from the precursors 1 (L = CO, for 4) and 2 (L = NCMe, for 3a-d), respectively. All products were characterized by IR and multinuclear NMR spectroscopy, and the structures of 3b and 3d were ascertained by X-ray diffraction studies. The behavior of the complexes in aqueous solutions (solubility, Log P, stability) was assessed using NMR and UV-Vis methods.
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- A systematic review was conducted to indirectly compare the effectiveness and safety of three long-acting growth hormones (LAGHs): somapacitan, somatrogon, and lonapegsomatropin, for treating growth hormone deficiency in children.
- The analysis found that after 52 weeks, there were no significant differences in growth outcomes among the LAGHs and daily growth hormone treatment, indicating that all options were similarly effective and generally well-tolerated.
- However, somatrogon was noted to cause injection site pain more frequently than the other treatments, but overall safety and efficacy profiles were comparable across all treatments.