Publications by authors named "Annabelle Briand"
Objective: To assess whether beta-lactam extended or continuous beta-lactam infusions (EI/CI) improve clinical outcomes in children with proven or suspected bacterial infections.
Study Design: We included observational and interventional studies that compared beta-lactam EI or CI with standard infusions in children less than 18 years old, and reported on mortality, hospital or intensive care unit length of stay, microbiological cure, and/or clinical cure. Data sources included PubMed, Medline, EBM Reviews, EMBASE, and CINAHL and were searched from January 1, 1980, to November 3, 2023.
Article Synopsis
- The study investigates the optimal dosing of Ganciclovir (GCV) and its prodrug Valganciclovir (VGCV) for preventing and treating cytomegalovirus in pediatric transplant recipients, due to significant variability in how children metabolize these drugs.
- A population pharmacokinetic analysis was conducted with data from 50 pediatric patients, demonstrating that factors like body weight and kidney function significantly affect drug clearance and distribution.
- Results indicate that the currently recommended doses have low success rates in achieving therapeutic targets, suggesting the need for therapeutic drug monitoring to improve patient outcomes.