Publications by authors named "Anna-Riina Koskenniemi"
Article Synopsis
- Cancer cells experience significant changes in gene expression and epigenetics, including the abnormal activation of certain tissue-specific genes.
- The RNA helicase DDX4 forms structures similar to germ granules in tumors but not in cultured cancer cells, containing proteins linked to RNA and splicing.
- The absence of DDX4 in cancer cells alters gene expression, reduces cancer growth and invasiveness, and is associated with poorer patient outcomes in certain cancers like head and neck squamous cell carcinoma and advanced prostate cancer.
Background: Hypoxia inducible factors, HIF-1α and HIF-2α, and their main regulators, the prolyl hydroxylase domain proteins (PHDs), mediate cellular response to hypoxia and contribute to tumor progression in clear cell renal cell carcinoma (ccRCC). These biomarkers may improve the value of traditional histopathological features in predicting disease progression after nephrectomy for localized ccRCC and guide patient selection for adjuvant treatments.
Patients And Methods: In this study, we analyzed the associations of PHD2 and PHD3 with histopathological tumor features and recurrence-free survival (RFS) in a retrospective cohort of 173 patients who had undergone surgery for localized ccRCC at Helsinki University Hospital (HUH), Finland.
Purpose: To evaluate the expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter1 (LAT1) in prostate cancer (PCa) and their impact on uptake of F-1-amino-3-fluorocyclobutane-1-carboxylic acid (F-fluciclovine) which is approved for the detection of recurrent PCa.
Methods: Twenty-five hormone-naïve patients with histologically confirmed PCa underwent PET/CT before prostatectomy. Dynamic imaging was performed immediately after injection of 368 ± 10 MBq of F-fluciclovine and the uptake in PCa was expressed as SUV at six sequential 4-min time frames and as tracer distribution volume (V) using Logan plots over 0-24 min.