Publications by authors named "Anna-Maria Prandstetter"

Successful pregnancy relies directly on the placenta's complex, dynamic, gene-regulatory networks. Disruption of this vast collection of intercellular and intracellular programs leads to pregnancy complications and developmental defects. In the present study, we generated a comprehensive, spatially resolved, multimodal cell census elucidating the molecular architecture of the first trimester human placenta.

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Article Synopsis
  • The placenta forms alongside the embryo, providing essential nourishment during development, with low oxygen levels initially present that later increase as the placenta takes over.
  • Human trophoblast stem cells (hTSC) can thrive in low oxygen, but their differentiation into important placental cell types is hindered by prolonged hypoxia, leading to potential placental disorders.
  • The factor GCM1 plays a crucial role in promoting differentiation; its downregulation in low oxygen correlates with reduced expression of genes necessary for cell differentiation, affecting the formation and function of key placental cells.
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Correct placental development and function are essential for adapting the mother to the ongoing pregnancy and the wellbeing of the growing fetus; however, underlying processes are still poorly understood. Only limited structural and cellular placental features are shared among species hence requiring reliable human in-vitro models. Recently established trophoblast stem cell and organoid models significantly improved placental research; however, the human placenta constitutes a multi-cellular organ with tightly orchestrated, cellular and molecular networks between trophoblasts (TBs) and villous core cells (VCCs) vital for correct placentation.

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