Publications by authors named "Anna-Maria Ochocka-Fox"
Article Synopsis
- Lymph nodes (LNs) are important in detecting colorectal cancer spread, but traditional imaging methods like CT and MRI have limitations in accurately assessing them.
- B-mode and contrast-enhanced ultrasound (CEUS) could enhance LN detection, but further research is needed before they can be widely adopted in clinical settings.
- A pilot study using a mouse model found that a new scoring system based on various LN characteristics may provide better predictive accuracy for cancer involvement than simply measuring LN size.
Colorectal cancer (CRC) is a common, multifactorial disease. While observational studies have identified an association between lower vitamin D and higher CRC risk, supplementation trials have been inconclusive and the mechanisms by which vitamin D may modulate CRC risk are not well understood. We sought to perform a weighted gene co-expression network analysis (WGCNA) to identify modules present after vitamin D supplementation (when plasma vitamin D level was sufficient) which were absent before supplementation, and then to identify influential genes in those modules.
View Article and Find Full Text PDFBackground & Aims: Aspirin reduces colorectal cancer (CRC) incidence and mortality. Understanding the biology responsible for this protective effect is key to developing biomarker-led approaches for rational clinical use. Wnt signaling drives CRC development from initiation to progression through regulation of epithelial-mesenchymal transition (EMT) and cancer stem cell populations.
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