Publications by authors named "Anna-Maria Franco Yusti"
Background: Few data are available on the real-world efficacy of receiving tenofovir-lamivudine-dolutegravir (DTG) as HIV treatment, particularly among young people in West Africa. Here, we evaluated pharmaco-virological outcomes and resistance profiles among Togolese children and adolescents.
Methods: A cross-sectional study was conducted in Lomé, Togo, enrolling antiretroviral-treated people with HIV aged from 18 months to 24 years.
Background: Advances in high-throughput sequencing (HTS) technologies and reductions in sequencing costs have revolutionised the study of genomics and molecular biology by making whole-genome sequencing (WGS) accessible to many laboratories. However, the analysis of WGS data requires significant computational effort, which is the major drawback in implementing WGS as a routine laboratory technique.
Objective: Automated pipelines have been developed to overcome this issue, but they do not exist for all organisms.
Article Synopsis
- Immunocompromised individuals tend to experience longer SARS-CoV-2 infections, increasing the chances for new mutations, especially in the spike protein, which is important for vaccines.
- A study in Paris analyzed samples from 444 immunocompromised patients and 234 healthcare workers, finding greater genetic diversity of the virus in the immunocompromised group.
- The research indicated that mutations in the viruses from immunocompromised patients contributed to the evolution of new variants, suggesting potential concerns for immune response and severity of future infections.
Although France was one of the most affected European countries by the COVID-19 pandemic in 2020, the dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) movement within France, but also involving France in Europe and in the world, remain only partially characterized in this timeframe. Here, we analyzed GISAID deposited sequences from January 1 to December 31, 2020 ( = 638,706 sequences at the time of writing). To tackle the challenging number of sequences without the bias of analyzing a single subsample of sequences, we produced 100 subsamples of sequences and related phylogenetic trees from the whole dataset for different geographic scales (worldwide, European countries, and French administrative regions) and time periods (from January 1 to July 25, 2020, and from July 26 to December 31, 2020).
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