Is there an influence of perceptual or cognitive impairment on complex sentence processing in hearing aid users?

Background: Hearing-impaired listeners often have difficulty understanding complex sentences. It is not clear if perceptual or cognitive deficits have more impact on reduced language processing abilities, and how a hearing aid might compensate for that.

Methods: In a prospective study with 5 hearing aid users and 5 normal hearing, age-matched participants, processing of complex sentences was investigated.

Impact of distant peptide substrate residues on enzymatic activity of SlyD.

Peptidyl-prolyl isomerases (PPIases) catalyze intrinsically slow and often rate-limiting isomerization of prolyl-peptide bonds in unfolded or partially folded proteins, thereby speeding up the folding process and preventing misfolding. They often possess binding and chaperone domains in addition to the domain carrying the isomerization activity. Although generally, their substrates display no identity in their amino acid sequence upstream and downstream of the proline with 20 possibilities for each residue, PPIases are efficient enzymes.