Publications by authors named "Anna-Lena Vollbrecht"
Article Synopsis
- Neurodegenerative diseases like tauopathies are linked to abnormal protein aggregation, particularly involving hyperphosphorylated Tau, which is influenced by the serotonin receptor 7 (5-HT7R) through the activation of cyclin-dependent kinase 5 (CDK5).
- The study utilized various scientific methods to analyze how 5-HT7R interacts with CDK5, discovering that specific regions of 5-HT7R are crucial for this interaction and identifying key phenylalanine residues that impact complex formation.
- The findings suggest that targeting the interaction between 5-HT7R and CDK5 could lead to new treatments for diseases related to Tau aggregation, offering a potential pathway for drug development.
Tauopathies comprise a heterogeneous family of neurodegenerative diseases characterized by pathological accumulation of hyperphosphorylated Tau protein. Pathological changes in serotonergic signaling have been associated with tauopathy etiology, but the underlying mechanisms remain poorly understood. Here, we studied the role of the serotonin receptor 7 (5-HT7R), in a mouse model of tauopathy induced by overexpressing the human Tau[R406W] mutant associated with inherited forms of frontotemporal dementia.
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