Publications by authors named "Anna-Lena Meinhardt"
Extrapulmonary small cell carcinomas (ESCCs) are poorly differentiated neuroendocrine tumors that are characterized by an aggressive course and poor survival rates. While these tumors can be found anywhere in the body, presentations of lesions in the orbit are exceedingly rare. We present the case of a 47-year-old man who presented with blurry vision, lacrimation, and tenderness of his right eye, as well as a small but palpable temporal mass.
View Article and Find Full Text PDFMultiple myeloma is a neoplastic disease of plasma cells. Plasma cell disorders can present as a single lesion (solitary plasmacytoma) or as multiple lesions (multiple myeloma). Solitary plasmacytomas can occur in bone (plasmacytoma of bone) or in soft tissues (extramedullary plasmacytoma), and both can serve as a precursor lesion to multiple myeloma.
View Article and Find Full Text PDFA variety of cancer entities are driven by KRAS mutations, which remain difficult to target clinically. Survival pathways, such as resistance to cell death, may represent a promising treatment approach in KRAS mutated cancers. Based on the frequently observed genomic deletions of BCL-2-related ovarian killer (BOK) in cancer patients, we explored the function of BOK in a mutant Kras-driven murine model of lung cancer.
View Article and Find Full Text PDFArticle Synopsis
- Evasion of programmed cell death is a key factor in cancer survival, particularly in non-small cell lung cancer (NSCLC), where understanding how cancer cells resist stress can help develop new treatments.* -
- Researchers found that the pro-survival gene MCL-1 frequently increases in NSCLC, both within cancer cell populations (clonally) and in individual cells (subclonally), and this is linked to the loss of the tumor suppressor gene TP53.* -
- In animal studies, inhibiting MCL-1 either through drugs or genetics slowed down tumor growth, suggesting that targeting MCL-1 could be a promising therapeutic strategy in lung adenocarcinoma.*
Tumor volume is a parameter used to evaluate the performance of new therapies in lung cancer research. Conventional methods that are used to estimate tumor size in mouse models fail to provide fast and reliable volumetric data for tumors grown non-subcutaneously. Here, we evaluated the use of iodine-staining combined with micro-computed tomography (micro-CT) to estimate the tumor volume of ex vivo tumor-burdened lungs.
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