Publications by authors named "Anna-Katharina Ehlert"
The L.p.SG1 DETECT Kit is a rapid, quantitative method for the detection and enumeration of Legionella pneumophila serogroup 1 (L.
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- The HIV-1 envelope trimer has a unique structure that protects sensitive areas from being targeted by antibodies, making it difficult for the immune system or vaccines to effectively neutralize the virus.
- This study uses a mathematical model to show that interactions between certain loops (V1V2 and V3) in the trimer help it avoid neutralization.
- Understanding how these loops work together can provide insights for developing better vaccines against HIV-1 by revealing how they shield important virus features.
The mechanisms of how Th cells promote CD8(+) T cell responses during viral infections are largely unknown. In this study, we unraveled the mechanisms of T cell help for CD8(+) T cell responses during vaccinia virus infection. Our results demonstrate that Th cells promote vaccinia virus-specific CD8(+) T cell responses via two interconnected synergistic pathways: First, CD40L expressed by activated CD4(+) T cells instructs dendritic cells to produce bioactive IL-12p70, which is directly sensed by Ag-specific CD8(+) T cells, resulting in increased IL-2Rα expression.
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