The Orchestra and Its Maestro: Shigella's Fine-Tuning of the Inflammasome Platforms.

Shigella spp. are the causative agents of bacillary dysentery, leading to extensive mortality and morbidity worldwide. These facultative intracellular bacteria invade the epithelium of the colon and the rectum, inducing a severe inflammatory response from which the symptoms of the disease originate.

Cortical processing of tactile direction discrimination based on spatiotemporal cues in man.

Tactile direction discrimination (TDD), the ability to determine the direction of an object's movement across the skin, is used clinically to detect and quantify tactile dysfunction. We have previously identified a cortical network for TDD based on skin stretch information that includes the second somatosensory, anterior insular and dorsolateral prefrontal cortices. In the present study we investigated cortical processing of TDD based on spatiotemporal cues.