Publications by authors named "Anna Zitova"
Article Synopsis
- - Our study investigates the origins of the vertebrate head using amphioxus, which shares traits with early chordates, by employing techniques like single-cell transcriptomics and signaling pathway analysis.
- - We identified different types of cells in amphioxus embryos that are similar to those involved in vertebrate head development, particularly focusing on prechordal plate-like and neural crest-like cells.
- - The research shows that key signaling pathways (Nodal, Hedgehog, and Wnt) are conserved in both vertebrates and amphioxus, suggesting that the mechanisms of head development can be traced back to a common ancestor of all chordates.
Conditional gene targeting in mice by means of Cre-loxP strategy represents a powerful approach to study mammalian gene function. This approach is however dependent on the availability of suitable strains of mice with a tissue or time restricted activity of the Cre recombinase. Here we describe Aldh3-Cre transgenic mice as a useful tool to conditionally delete genes in cornea, a specialized transparent tissue found on the anterior-most part of the eye, which acts as a protective barrier and contributes to the refractive power.
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