Contributions of the individual domains of αβ integrin to its extension: Insights from multiscale modeling.

The platelet integrin αβ undergoes long-range conformational transitions between bent and extended conformations to regulate platelet aggregation during hemostasis and thrombosis. However, how exactly αβ transitions between conformations remains largely elusive. Here, we studied how transitions across bent and extended-closed conformations of αβ integrin are regulated by effective interactions between its functional domains.