Presentation, management, and outcomes of cauda equina syndrome up to one year after surgery, using clinician and participant reporting: A multi-centre prospective cohort study.

Background: Cauda equina syndrome (CES) results from nerve root compression in the lumbosacral spine, usually due to a prolapsed intervertebral disc. Evidence for management of CES is limited by its infrequent occurrence and lack of standardised clinical definitions and outcome measures.

Methods: This is a prospective multi-centre observational cohort study of adults with CES in the UK.

Management of C2 odontoid peg fragility fractures - A UK survey of spinal surgeons.

Purpose: Patients sustaining fragility fractures of the C2 odontoid peg have 30-day mortality rates as high as 10% rising up to 34.1% at 1 year. Substantial controversy exists regarding optimal management of these fractures and there is a lack of national guidance to inform best practice.

Reduction in intestinal colonization and invasion of internal organs after challenge by homologous and heterologous serovars of following vaccination of chickens with a novel trivalent inactivated vaccine.

A novel inactivated vaccine, comprising three serovars of (Enteritidis, serogroup O:9; Typhimurium, serogroup O:4; Infantis, serogroup O:7) grown under conditions of iron restriction and adjuvanted with aluminium hydroxide, was evaluated for efficacy following challenge by homologous and heterologous serovars. Chickens were vaccinated at 6 and 10 weeks of age by the intramuscular route and challenged 4 to 9 weeks after the second vaccination with serovars belonging to serogroup O:9 (Enteritidis), O:4 (Typhimurium and Heidelberg), O:7 (Infantis and Virchow), and O:8 (Hadar). All vaccinated birds produced a marked systemic antibody response against each of the component vaccine antigens by the time of challenge.

Younger age is a risk factor for regrowth and recurrence of nonfunctioning pituitary macroadenomas: Results from a single Australian centre.

Objective: The natural history of nonfunctioning pituitary macroadenomas (NFPMA) after surgical resection is variable, with guidelines unable to define the duration of radiological follow-up. In this first Australian series, we identify risk factors for regrowth/recurrence of NFPMA to assist with guiding recommendations for long-term follow-up.

Design: Retrospective analysis of all radiotherapy-naïve cases with NFPMA resected between 1995 and 2013.

Cadaveric Spinal Surgery Simulation: A Comparison of Cadaver Types.

Study Design Single-blinded study. Objective To assess the suitability of three types of cadaver for simulating pedicle screw insertion and establish if there is an ideal. Methods Three types of cadaver-Thiel-embalmed, Crosado-embalmed, and formaldehyde-embalmed-were draped and the spines exposed.

A quality assessment of respiratory auscultation material on YouTube.

YouTube contains a large volume of medical educational material. This study assessed the quality of respiratory auscultation videos contained in YouTube. Videos were searched for using the terms 'breath sounds', 'respiratory sounds', 'respiratory auscultation' and/or 'lung sounds'.

Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence.

Unlabelled: Cellular senescence is an irreversible side effect of some pharmaceuticals which can contribute to tissue degeneration.

Objective: To determine whether pharmaceutical glucocorticoids induce senescence in tenocytes.

Methods: Features of senescence (β-galactosidase activity at pH 6 (SA-β-gal) and active mammalian/mechanistic target of rapamycin (mTOR) in cell cycle arrest) as well as the activity of the two main pathways leading to cell senescence were examined in glucocorticoid-treated primary human tenocytes.

Constraints on neutron star crusts from oscillations in giant flares.

We show that the fundamental seismic shear mode, observed as a quasiperiodic oscillation in giant flares emitted by highly magnetized neutron stars, is particularly sensitive to the nuclear physics of the crust. The identification of an oscillation at approximately 30 Hz as the fundamental crustal shear mode requires a nuclear symmetry energy that depends very weakly on density near saturation. If the nuclear symmetry energy varies more strongly with density, then lower frequency oscillations, previously identified as torsional Alfvén modes of the fluid core, could instead be associated with the crust.