Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult .

Limb regeneration is a frontier in biomedical science. Identifying triggers of innate morphogenetic responses in vivo to induce the growth of healthy patterned tissue would address the needs of millions of patients, from diabetics to victims of trauma. Organisms such as -whose limited regenerative capacities in adulthood mirror those of humans-are important models with which to test interventions that can restore form and function.

Gli3 repressor controls cell fates and cell adhesion for proper establishment of neurogenic niche.

Neural stem cells (NSCs) in the subventricular zone (SVZ) rely on environmental signals provided by the neurogenic niche for their proper function. However, little is known about the initial steps of niche establishment, as embryonic radial glia transition to postnatal NSCs. Here, we identify Gli3 repressor (Gli3R), a component of the Sonic hedgehog (Shh) pathway, as a critical factor controlling both cell-type specification and structural organization of the developing SVZ.