Publications by authors named "Anna Victoria Serbin"
Article Synopsis
- Early life stress (ELS) in mice leads to cognitive issues and changes in dopamine receptor expression in the male offspring's anterior cingulate cortex (ACC).
- Fragmented maternal care during a critical neonatal period resulted in elevated D2R and suppressed D4R, impairing performance on visual attention tasks, but this could be reversed in adulthood through pharmacological interventions.
- ELS male mice also exhibited increased hypothalamic orexin and disrupted sleep patterns, pointing to sleep loss as a possible underlying factor for cognitive deficits, a correlation that extends to attention issues observed in children who experienced early adversity.
Severe congenital neutropenia (SCN) is a life-threatening disorder most often caused by dominant mutations of ELANE that interfere with neutrophil maturation. We conducted a pooled CRISPR screen in human hematopoietic stem and progenitor cells (HSPCs) that correlated ELANE mutations with neutrophil maturation potential. Highly efficient gene editing of early exons elicited nonsense-mediated decay (NMD), overcame neutrophil maturation arrest in HSPCs from ELANE-mutant SCN patients, and produced normal hematopoietic engraftment function.
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