Publications by authors named "Anna Veronika Hipp"
Article Synopsis
- The text discusses interleukin 17 (IL-17)-producing CD8 T cells, known as Tc17 cells, highlighting their role in mucosal defense and inflammatory responses in diseases like psoriasis, multiple sclerosis, and inflammatory bowel disease.
- It aims to summarize current understanding of the characteristics, development, and generation of Tc17 cells.
- The review also examines the involvement of Tc17 cells in various human conditions, including infectious diseases, cancer, and immune-related disorders.
Background & Aims: Exhaustion of CD8 T cells has been suggested to inform different clinical outcomes in Crohn's disease, but detailed analyses are lacking. This study aimed to identify the role of exhaustion on a single-cell level and identify relevant CD8 T cell populations in Crohn's disease.
Methods: Blood and intestinal tissue from 58 patients with Crohn's disease (active disease or remission) were assessed for CD8 T cell expression of exhaustion markers and their cytokine profile by highly multiplexed flow and mass cytometry.