Characterization of Forced Degradation Products of Netarsudil: Optimization and Validation of a Stability-Indicating RP-HPLC Method for Simultaneous Quantification of Process-Related Impurities.

Objectives: The aim of this study is to examine resolution, identification, and characterization of forced degradation products of netarsudil by liquid chromatography-tandem mass spectrometry by validating a simple and sensitive high-performance liquid chromatography method for the resolution, identification, and quantification of two process-related impurities in netarsudil.

Materials And Methods: Chromatographic separation was accomplished on a ZORBAX Eclipse XDB C18 (250 x 4.6 mm; 5 µ id) column at room temperature as the stationary phase and 257 nm as the detector wavelength with the mobile phase consisting of acetonitrile, methanol, and pH 4.

Data on road traffic incidents for Sydney greater metropolitan area.

A road network aims to facilitate the movement of commuters and goods in a safe, economical, and efficient way that contributes to growth in the economy. Road traffic incidents (RTIs), such as crashes, vehicle breakdowns, hazards, etc., are unexpected events that cause severe traffic congestion, unreliability, and pollution.

Determinants of speed variability on the horizontal curves of two-lane undivided rural highways passing through mountainous terrain.

Drivers traversing the horizontal curves are expected to complete the deceleration manoeuvre on the tangent and transition curve and maintain a constant speed upon reaching the curve. However, this may not be true for the horizontal curves constituting a two-lane undivided rural highway passing through mountainous terrain. The objective of this study is to investigate the speed variability on a two-lane rural highway passing through mountainous terrain and to identify its determinants.

Computational exploration of Cu(II)-en chelate-catalyzed hydrolysis of O-isopropyl methylphosphonofluoridate.

Context: In contrast to un-catalyzed hydrolysis of organophosphorus (OP) compounds, metal ions or/and their complexes with chelating ligands show catalytic effects in several ways depending upon the nature of the metal, ligand, substrate, and medium. It is known that Cu(II)-en chelate containing copper complexes accelerate the hydrolysis of OP compounds. However, the mechanism for this rate enhancement in the Cu(II)-en chelate catalytic hydrolysis reaction of sarin remains unexplored.

Rapid Stability Indicating HPLC Method for the Analysis of Leflunomide and Its Related Impurities in Bulk Drug and Formulations.

Objectives: Leflunomide (LFNM) is a drug that belongs to isoxazole derivatives and has immunosuppressive and anti-inflammatory activities. A literature search confirms that there is no method reported for the simultaneous estimation of LFNM and its related impurities A and B in pharmaceutical dosage forms or in bulk drug. Hence the present work aimed to develop a simple stability indicating RP-HPLC method for the separation and quantification of LFNM and its impurities A and B.

Prediction of maxillary canine impaction based on panoramic radiographs.

Objectives: The objective of this article is to establish a large sample-based prediction model for maxillary canine impaction based on linear and angular measurements on panoramic radiographs and to validate this model.

Materials And Methods: All patients with at least two panoramic radiographs taken between the ages of 7 and 14 years with an interval of minimum 1 year and maximum 3 years (T1 and T2) were selected from the Department of Oral Health Sciences, University Hospital Leuven database. Linear and angular measurements were performed at T1.

C-H Activation and Proton Transfer Initiate Alkene Metathesis Activity of the Tungsten(IV)-Oxo Complex.

In alkene metathesis, while group 6 (Mo or W) high-oxidation state alkylidenes are accepted to be key reaction intermediates for both homogeneous and heterogeneous catalysts, it has been proposed that low valent species in their +4 oxidation state can serve as precatalysts. However, the activation mechanism for these latter species-generating alkylidenes-is still an open question. Here, we report the syntheses of tungsten(IV)-oxo bisalkoxide molecular complexes stabilized by pyridine ligands, WO(OR)py (R = CMe(CF) (2a), R = Si(O tBu) (2b), and R = C(CF) (2c); py = pyridine), and show that upon activation with B(CF) they display alkene metathesis activities comparable to W(VI)-oxo alkylidenes.

Parasites of stray and client-owned domestic cats in urban areas in Russia during 2000-2015 years.

Cats are commonly infected by many species of parasites that includes helminths, protozoan parasites, mites and fleas. Parasites affect the health of cats and cause morbidity and mortality, especially in young and old animals. Some species such as Ancylostoma spp.

Heart rate variability as predictive factor for sudden cardiac death.

Sudden cardiac death (SCD) represents about 25% of deaths in clinical cardiology. The identification of risk factors for SCD is the philosopher's stone of cardiology and the identification of non-invasive markers of risk of SCD remains one of the most important goals for the scientific community.The aim of this review is to analyze the state of the art around the heart rate variability (HRV) as a predictor factor for SCD.

Di-hydrogen contact induced lattice instabilities and structural dynamics in complex hydride perovskites.

The structural phase transitions occurring in a series of perovskite-type complex hydrides based on the tetrahydroborate anion BH4(-) are investigated by means of in situ synchrotron x-ray powder diffraction, vibrational spectroscopy, thermal methods and ab initio calculations in the solid state. Structural dynamics of the BH4 anion are followed with quasi-elastic neutron scattering. We show that unexpected temperature-induced lattice instabilities in perovskite-type ACa(BH4)3 (A = K, Rb, Cs) have their origin in close hydridic di-hydrogen contacts.

Combined administration of oxycodone/naloxone in chronic osteo-articular diseases pain therapy.

The aim of this study is the analysis of the beneficial impact of using opioid receptor antagonist associated to opioid analgesic on the quality of life in patients suffering from chronic non-cancer pain. We recruited 60 patients suffering from osteo-articular diseases who were randomized into two groups of treatment. The group A was treated with the association of opioid receptor antagonist and opioid agonist, represented by Oxycodone.

FT-IR spectra of inorganic borohydrides.

Inorganic compounds with BH4(-) ions are the subject of many recent investigations in the context of potential hydrogen storage materials. In this work, Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectra of a series of reference and research compounds (including deuterated samples) are collected and made available to the research community.

Hydrogen-fluorine exchange in NaBH4-NaBF4.

Hydrogen-fluorine exchange in the NaBH4-NaBF4 system is investigated using a range of experimental methods combined with DFT calculations and a possible mechanism for the reactions is proposed. Fluorine substitution is observed using in situ synchrotron radiation powder X-ray diffraction (SR-PXD) as a new Rock salt type compound with idealized composition NaBF2H2 in the temperature range T = 200 to 215 °C. Combined use of solid-state (19)F MAS NMR, FT-IR and DFT calculations supports the formation of a BF2H2(-) complex ion, reproducing the observation of a (19)F chemical shift at -144.

Novel sodium aluminium borohydride containing the complex anion [Al(BH4,Cl)4]-.

The synthesis of a novel alkali-metal aluminium borohydride NaAl(BH4)xCl4-x from NaBH4 and AlCl3 using a solid state metathesis reaction is described. Structure determination was carried out using synchrotron powder diffraction data and vibrational spectroscopy. An orthorhombic structure (space group Pmn2(1)) is formed which contains Na+ cations and complex [Al(BH4,Cl)4]- anions.

GC determination of N-nitrosamines by supersonic molecular beam MS equipped with triple quadrupole analyzer, GC/SMB/QQQ/MS.

The determination of 14 N-nitrosamines by a supersonic molecular beam electron ionization mass spectrometer equipped with triple quadruple analyzer, GC/SMB/EI/QQQ/MS is presented. The supersonic molecular beam electron ionization ion source allows the elucidation of the molecular ion of 13 out of the 14 examined nitrosamines (except for diphenylnitrosamine which was degraded before the analysis). It was possible to use the molecular ions of all the nitrosamines as the parent ions for multiple reactions monitoring mode, which in turn allows significant increase of specificity and lowering of the method limit of detection of the higher molecular weight nitrosamines.

Al3Li4(BH4)13: a complex double-cation borohydride with a new structure.

The new double-cation Al-Li-borohydride is an attractive candidate material for hydrogen storage due to a very low hydrogen desorption temperature (approximately 70 degrees C) combined with a high hydrogen density (17.2 wt%). It was synthesised by high-energy ball milling of AlCl(3) and LiBH(4).

[New trends in the laboratory diagnostics of proteinuria and albuminuria].

According to current clinical trials, albumin excretion is an early indicator of cardiovascular damage. While proteinuria is considered as a marker of kidney function, albuminuria indicates cardiovascular risk first of all. Sensitivity of the previous laboratory tests does not meet the clinical requirements, and the error of urine collection makes the results misleading.

Effectiveness of blood pressure lowering: evidence-based comparisons between men and women.

The global burden of blood pressure-related disease is escalating faster among women than among men and, in recent years, age-adjusted mortality rates among women have actually increased. This has led to the speculation that there might be major sex-specific differences in the effectiveness of preventive therapies such as blood pressure-lowering drugs. However, large overviews of both observational and clinical trial data provide strong evidence that the protection against serious vascular events afforded by blood pressure reduction using a range of commonly used drugs is comparable for men and women.

DFT studies on catalytic properties of isolated and carbon nanotube supported Pd9 cluster. Part II. Hydro-isomerization of butene isomers.

The processes involved in the butene hydro-isomerization, occurring on a small palladium cluster in the presence of dissociated hydrogen, have been investigated by means of DFT and DFT/MM approaches. This study has been performed both on an isolated (unsupported) Pd(9) cluster and on the same cluster when it is supported on a portion of a single-walled armchair(6,6) carbon nanotube. The study follows another investigation which has already been published concerning the adsorption, fragmentation and diffusion of hydrogen on the same metal cluster.

Synthesis and characterization of NaBD3H, a potential structural probe for hydrogen storage materials.

Specifically labeled NaBD(3)H has been synthesized and characterized using X-ray diffraction, NMR, and vibrational spectroscopy. The isotopic purity of the compound, as estimated from NMR spectra, was found to be about 85% with the compound NaBD(2)H(2) as the second product. IR spectra confirm the relatively strong intensity of the single B-H stretching mode predicted from DFT calculations.

Frequency of migraine and the risk of cardiovascular disease for women: limited evidence of an association.

Evaluation of: Kurth T, Schurks M, Logroscino G et al. Migraine frequency and risk of cardiovascular disease in women. Neurology 73, 581-588 (2009).