Prenatal exposure to valproic acid disturbs the enkephalinergic system functioning, basal hedonic tone, and emotional responses in an animal model of autism.

Rationale: It has been suggested that behavioral aberrations observed in autism could be the result of dysfunction of the neuroregulatory role performed by the endogenous opioid peptides. Many of those aberrations have been recently modeled in rats exposed to valproic acid (VPA) on the 12th day of gestation (VPA rats).

Objectives: The aim of the present study was to elucidate functioning of the enkephalinergic system, one of the endogenous opioid peptide systems strongly involved in emotional responses, in VPA rats using both biochemical and behavioral methods.

Accumulation of nodularin in sediments, mussels, and fish from the Gulf of Gdańsk, southern Baltic Sea.

In the Gulf of Gdańsk, as in other parts of the Baltic Sea, toxic blooms of Nodularia spumigena are an annual phenomenon. In the present work, the accumulation of nodularin (NOD), a cyanobacterial pentapeptide hepatotoxin, in sediments, blue mussels, and flounders from the Gulf of Gdańsk was studied by enzyme-linked immunosorbent assay (ELISA). In the surface layers of the sediments NOD concentration ranged from 2.