Publications by authors named "Anna Tobiasch"
Article Synopsis
- Sepsis-induced DIC is a serious condition with high morbidity and mortality, and factors like endothelial injury and extracellular vesicles (EV) are crucial in its development.
- The study examined the role of E-selectin, EV, tissue factor (TF), and tissue factor pathway inhibitor (TFPI) in identifying sepsis-induced coagulopathy by analyzing plasma samples from 87 sepsis patients.
- Findings indicated that while only TFPI and TF-PCA levels could effectively discriminate between patients with and without DIC, higher levels of TFPI specifically correlated with worsening DIC, suggesting that these markers could enhance diagnosis and treatment strategies in septic patients.
Article Synopsis
- Coagulopathy and organ dysfunctions are critical features of sepsis, and a study explored the role of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in septic shock patients.
- In the study, patients with septic shock had significantly higher levels of both TF and TFPI compared to healthy controls, with differences in their ratios possibly indicating disease severity and outcomes.
- The research findings suggest that a high TF/TFPI ratio is linked specifically to heart injury in septic patients, while elevated TFPI levels correlate with multiple organ dysfunctions and overall disease severity.
Blood clot formation, a crucial process in hemostasis and thrombosis, has garnered substantial attention for its implications in various medical conditions. Microscopic examination of blood clots provides vital insights into their composition and structure, aiding in the understanding of clot pathophysiology and the development of targeted therapeutic strategies. This study explores the use of topological data analysis (TDA) to assess plasma clot characteristics microscopically, focusing on the identification of the elements components, holes and Wasserstein distances.
View Article and Find Full Text PDF