Microstructure evolution and catalytic activity of AlCoFeNiTiMo high entropy alloys fabricated by powder metallurgy route.

This investigation presents the synthesis of equiatomic and non-equiatomic AlCoFeNiTiMo (x = 0, 0.1, 0.25 and 1.

Effect of different fillers on thermal conductivity, tribological properties of Polyamide 6.

An influence of different filler types and filler content on the thermal and abrasive wear properties of polyamide-6 is investigated. AlO, MgO, two glass powders with different SiO contents, and natural zeolite powder were selected as fillers. The fillers individually were added to the polymer matrix in proportions of 50 and 70% by weight.

Aberrant Splicing of Impairs Beta-Cell Differentiation and Proliferation by ER Stress in the Isogenic iPSC Model of Neonatal Diabetes.

One of the causes of diabetes in infants is the defect of the insulin gene (INS). Gene mutations can lead to proinsulin misfolding, an increased endoplasmic reticulum (ER) stress and possible beta-cell apoptosis. In humans, the mechanisms underlying beta-cell failure remain unclear.

Structural differences and adsorption behaviour of alkaline metals doped zinc oxide nanoparticles.

Nanotechnology plays a vital role in all the scientific fields including environmental research due to their surface: volume ratio compared to bulk materials. Recent studies prove their effectiveness as pollutant removal and remediation practices. Zinc oxide (ZnO) nanoparticles a multifunctional material with distinct properties and their doped counterparts were widely being studied in different fields of science.

Generation of an induced pluripotent stem cell line MNDINSi001-A from a patient with neonatal diabetes caused by a heterozygous INS mutation.

Insulin gene (INS) mutations prove to be the second most common cause of permanent neonatal diabetes. Here, we report the generation of iPSC line from a patient, heterozygous for the intronic INS mutation that presumably leads to aberrant splicing. Dermal fibroblasts were reprogrammed using non-integrating RNA-based vector.

Phase Transformation and Morphology Evolution of TiCuNiSn₅ during Mechanical Milling.

Nanocrystalline/amorphous powder was produced by ball milling of TiCuNiSn₅ (at.%) master alloy. Both laser diffraction particle size analyzer and scanning electron microscope (SEM) were used to monitor the changes in the particle size as well as in the shape of particles as a function of milling time.

Disruption of shape complementarity in the ribosomal protein L1-RNA contact region does not hinder specific recognition of the RNA target site.

The formation of a specific and stable complex between two (macro)molecules implies complementary contact surface regions. We used ribosomal protein L1, which specifically binds a target site on 23S rRNA, to study the influence of surface modifications on the protein-RNA affinity. The threonine residue in the universally conserved triad Thr-Met-Gly significant for RNA recognition and binding was substituted by phenylalanine, valine and alanine, respectively.

Generation of new TRAIL mutants DR5-A and DR5-B with improved selectivity to death receptor 5.

TRAIL (tumor necrosis factor (TNF) related apoptosis-inducing ligand) has been introduced as an extrinsic pathway inducer of apoptosis that does not have the toxicities of Fas and TNF. However, the therapeutic potential of TRAIL is limited because of many primary tumor cells are resistant to TRAIL. Despite intensive investigations, little is known in regards to the mechanisms underlying TRAIL selectivity and efficiency.