Activity of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in sera of patients with hepatitis C.

Introduction: The changes of enzyme activity in the hepatocytes in the course of different liver diseases are reflected by increase of the corresponding enzyme activity in the plasma. For example, the activities of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) correlate with the severity of the condition during cirrhosis. In this study we measured the activity of ADH isoenzymes and ALDH in the sera of patients with hepatitis C.

Serum Alcohol Dehydrogenase and Aldehyde Dehydrogenase Activity in the Course of Hepatitis C.

Background: Hepatistis C virus (HCV) affects approximately 170 million people, and it is the leading cause of the chronic liver disease. The destruction of liver cells is reflected by an increase of different enzyme activities in the serum. These enzymes include alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which play a significant role in the metabolism of many biological substances and exist mainly in the liver.

The alcohol dehydrogenase isoenzyme alcohol dehydrogenase IV as a candidate marker of Helicobacter pylori infection.

Introduction: Helicobacter pylori infection is associated with decreased alcohol dehydrogenase (ADH) activity in the gastric mucosa. The decrease in gastric ADH activity depends on the severity of inflammation and mucosal injury. This damage can be a reason of the release of enzyme from gastric mucosa and leads to the increase of the ADH activity in the sera of patients with H.

[The laboratory diagnostics of alcoholic disease].

Ethyl alcohol is metabolized in the body with the involvement of three metabolic pathways which are the system of alcohol dehydrogenase (ADH), the layout of the microsomal oxidation of alcohol (MEOS) and pathway of catalase. The above-mentioned routes are oxidative mechanisms for the elimination of alcohol and run in the liver. For the mechanism of oxidative metabolites of alcohol elimination include sialic acid, beta-hexosaminidase, carbohydrate-deficient transferrin, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, and 5-hydroxytryptophol.