Improved procedures of Sc(OH)3 precipitation and UTEVA extraction for 44Sc separation.

Background: 44Sc is becoming attractive as a PET radionuclide due to its decay characteristics. It can be produced from 44Ca present in natural calcium with 2.08% abundance.

Production of Sc medical radioisotopes with proton and deuteron beams.

Proton and deuteron beams (15.3 and 6.8 MeV, respectively) extracted from the PETtrace medical cyclotron at the Radiopharmaceuticals Production and Research Centre in the University of Warsaw, Heavy Ion Laboratory, 28 MeV protons from the C30 cyclotron at the National Centre for Nuclear Research, Świerk, near Warsaw and 33 MeV protons from the ARRONAX accelerator, Nantes were used to produce and investigate the medically interesting Sc radioisotopes.

Separation of Sc from Natural Calcium Carbonate Targets for Synthesis of Sc-DOTATATE.

The rapid increase in applications of scandium isotopes in nuclear medicine requires new efficient production routes for these radioisotopes. Recently, irradiations of calcium in cyclotrons by α, deuteron, and proton beams have been used. Therefore, effective post-irradiation separation and preconcentration of the radioactive scandium from the calcium matrix are important to obtain the pure final product in a relatively small volume.

At labeled substance P (5-11) as potential radiopharmaceutical for glioma treatment.

Introduction: The purposes of the present work were to label substance P (5-11) with At using a rhodium(III) complex with a bifunctional ligand-2-(1,5,9,13-tetrathiacyclohexadecan-3-yloxy)acetic acid ([16aneS]-COOH) and to assess the in vitro stability and toxicity of the obtained radiobioconjugate.

Methods: Two approaches were evaluated to obtain I/At-Rh[16aneS]-SP radiobioconjugates, based on 2-step and 1-step syntheses. In the first method I/At-Rh[16aneS]-COOH complexes were obtained that required further coupling to a biomolecule.

Production of medical Sc radioisotopes with an alpha particle beam.

The internal α-particle beam of the Warsaw Heavy Ion Cyclotron was used to produce research quantities of the medically interesting Sc radioisotopes from natural Ca and K and isotopically enriched Ca targets. The targets were made of metallic calcium, calcium carbonate and potassium chloride. New data on the production yields and impurities generated during the target irradiations are presented for the positron emitters Sc, Sc and Sc.

Cyclotron production of (43)Sc for PET imaging.

Background: Recently, significant interest in (44)Sc as a tracer for positron emission tomography (PET) imaging has been observed. Unfortunately, the co-emission by (44)Sc of high-energy γ rays (E γ = 1157, 1499 keV) causes a dangerous increase of the radiation dose to the patients and clinical staff. However, it is possible to produce another radionuclide of scandium-(43)Sc-having properties similar to (44)Sc but is characterized by much lower energy of the concurrent gamma emissions.

Fine plastic foil as backing for sputtered nickel targets.

Targets of Ni and Ni with areal density between 71 and 105 μg/cm backed with polyimide foil of 35-40 μg/cm were prepared by sputtering with Ar ions produced by a home made sputtering device at the Target Laboratory, University of Jyväskylä. The efficiency of the procedure was about 20 %.

Target preparation for research with charged projectiles.

The paper reviews in a compact format the techniques most frequently used for target preparation, such as rolling, powder compacting, and vacuum deposition. The survey covers also the techniques used for target characterisation (thickness, purity) and problems related to the extension of target life-time and time of uninterrupted experiments with use of targets.