Publications by authors named "Anna Stefaniuk"
Article Synopsis
- Nudt15 is a well-studied enzyme from the NUDIX protein family, primarily for its effects on thiopurine drugs used in cancer and inflammatory disease treatment.
- Besides its known activity on thiopurines, Nudt15 also acts on various nucleotide substrates, and there's speculation about its role in the degradation of mRNA through hydrolysis of mGDP.
- Recent research showed that Nudt15 has moderate activity with methylated forms of GDP and GTP, suggesting these can inform the design of new small molecule inhibitors targeting Nudt15.
Normal and heavy water are solvents most commonly used to study the isotope effect. The isotope effect of a solvent significantly influences the behavior of a single molecule in a solution, especially when there are interactions between the solvent and the solute. The influence of the isotope effect becomes more significant in DO/HO since the hydrogen bond in HO is slightly weaker than its counterpart (deuterium bond) in DO.
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