Publications by authors named "Anna Spiro"
Deep learning methods have recently become the state of the art in a variety of regulatory genomic tasks, including the prediction of gene expression from genomic DNA. As such, these methods promise to serve as important tools in interpreting the full spectrum of genetic variation observed in personal genomes. Previous evaluation strategies have assessed their predictions of gene expression across genomic regions; however, systematic benchmarking is lacking to assess their predictions across individuals, which would directly evaluate their utility as personal DNA interpreters.
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- There's a rising interest in using unsupervised deep learning for gene expression analysis, leading to the development of methods to improve model interpretability.
- These interpretability methods fall into two categories: post hoc analyses of complex models and the design of biologically-constrained models from the start.
- The authors suggest that combining these two approaches can be beneficial and introduce PAUSE, a method that pinpoints key sources of transcriptomic variation using both unsupervised learning and biologically-constrained neural networks.
Deep learning methods have recently become the state-of-the-art in a variety of regulatory genomic tasks including the prediction of gene expression from genomic DNA. As such, these methods promise to serve as important tools in interpreting the full spectrum of genetic variation observed in personal genomes. Previous evaluation strategies have assessed their predictions of gene expression across genomic regions, however, systematic benchmarking is lacking to assess their predictions across individuals, which would directly evaluates their utility as personal DNA interpreters.
View Article and Find Full Text PDFA tiered pediatric Asthma Population Health Management Program (APHMP), based on evidence-based practices, that differentially targets populations for intervention based on rising risk for high utilization and disease complications was implemented at 6 urban and suburban practices affiliated with an academic medical center. In addition to standard pediatric asthma care, APHMP adds regular administration of the asthma control test (ACT), provider education on performance variation, and monitoring through the electronic health record-based asthma registry. As patients' use of acute health care services and complications increases, APHMP integrates multidisciplinary interventions, including an asthma coach who conducts environmental assessments in addition to addressing social needs, into their primary care.
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- The role of community health workers (CHWs) is increasingly recognized in patient care legislation, highlighting their importance in healthcare delivery.
- A successful CHW program requires a well-structured system to ensure sustainability and effectiveness.
- The Massachusetts General Hospital Chelsea HealthCare Center showcases a unique CHW model that supports patients, providers, the community, and CHW staff, promoting a collaborative approach to healthcare.