Association of Social Determinants of Health With Brain MRI Outcomes in Individuals With Pediatric Onset Multiple Sclerosis.

Background And Objectives: Accumulating evidence points to worse clinical outcomes among adults with multiple sclerosis (MS) belonging to minority or poverty-affected groups. By contrast, little is known about the outcomes of these populations with pediatric-onset MS (POMS). Individuals with POMS represent 5% of the MS population and are more racially diverse yet have been understudied regarding socioeconomic environment or characteristics.

The Neurobiology of Infant Attachment-Trauma and Disruption of Parent-Infant Interactions.

Current clinical literature and supporting animal literature have shown that repeated and profound early-life adversity, especially when experienced within the caregiver-infant dyad, disrupts the trajectory of brain development to induce later-life expression of maladaptive behavior and pathology. What is less well understood is the immediate impact of repeated adversity during early life with the caregiver, especially since attachment to the caregiver occurs regardless of the quality of care the infant received including experiences of trauma. The focus of the present manuscript is to review the current literature on infant trauma within attachment, with an emphasis on animal research to define mechanisms and translate developmental child research.

Variability across repeated productions in bilingual children speaking Jamaican Creole and English.

Purpose: Previous work suggests that variability across repeated productions of the same word may be useful in diagnosing speech sound disorder (SSD) in bilingual children. However, there is debate over what level of variability in transcribed productions should be considered typical even in monolingual speech development. High variability in the input represents a factor that could promote increased production variability in bilinguals.

Speech Production Accuracy and Variability in Monolingual and Bilingual Children With Cochlear Implants: A Comparison to Their Peers With Normal Hearing.

Purpose This study investigates consonant and vowel accuracy and whole-word variability (also called token-to-token variability or token-to-token inconsistency) in bilingual Spanish-English and monolingual English-speaking children with cochlear implants (CIs) compared to their bilingual and monolingual peers with normal hearing (NH). Method Participants were 40 children between 4;6 and 7;11 (years;months; M = 6;2), n = 10 each in 4 participant groups: bilingual Spanish-English with CIs, monolingual English with CIs, bilingual Spanish-English with NH, and monolingual English with NH. Spanish and English word lists consisting of 20 words of varying length were generated, and 3 productions of each word were analyzed for percent consonants correct, percent vowels correct, and the presence of any consonant and/or vowel variability.

Association of the Type of Toy Used During Play With the Quantity and Quality of Parent-Infant Communication.

Importance: The early language environment of a child influences language outcome, which in turn affects reading and academic success. It is unknown which types of everyday activities promote the best language environment for children.

Objective: To investigate whether the type of toy used during play is associated with the parent-infant communicative interaction.

Predictors of token-to-token inconsistency in preschool children with typical speech-language development.

The purpose of this study was to examine potential concurrent predictors and replicate rates of token-to-token inconsistency (inconsistency in repeated productions of the same word) in 43 children with typical speech-language development, ages 2;6 to 4;2. A standard linear regression was used to determine which variables, if any, among age, expressive and receptive vocabulary, and speech sound production abilities predicted token-to-token inconsistency. Inconsistency rates in children from one research site, reported elsewhere, were compared to rates in children from a second research site.

Intraword variability in typical speech development.

Purpose: Intraword variability (sometimes called token-to-token variability) has been associated with certain types of speech disorder. It has also been documented in typical speech development. The purpose of this study was to investigate intraword variability in typically developing 2- and 3-year-olds to determine expected rates and patterns of variability in typical speech development.

Lexical and phonological effects in early word production.

Purpose: This study examines the influence of word frequency, phonological neighborhood density (PND), age of acquisition (AoA), and phonotactic probability on production variability and accuracy of known words by toddlers with no history of speech, hearing, or language disorders.

Method: Fifteen toddlers between 2;0 (years;months) and 2;5 produced monosyllabic target words varying in word frequency, PND, AoA, and phonotactic probability. Phonetic transcription was used to determine (a) whole-word variability and (b) proportion of whole-word proximity (PWP; Ingram, 2002) of each target word produced.

Insights on blastomere nuclearity.

Purpose: To analyze the results of our transferred embryos, especially those that "changed" their blastomere nuclearity from Multinucleated (MN) to Mono-nucleated during development.

Methods: Pregnancies where at least one MN embryo was transferred were retrospectively evaluated and categorized in order to record and follow-up on the ones that were implanted. Embryos were classified as normal (when all blastomeres were mono-nucleated on day one and two of development), corrected (multinucleated embryos on day one that became mono-nucleated on day two) and non-corrected (multinucleated either on day one, on day two or both days).

Monochorionic triplets after single embryo transfer.

A 40-year-old patient underwent intracytoplasmic sperm injection and assisted hatching, and a single embryo was transferred. Ultrasonography demonstrated a single gestational sac containing monochorionic tri-amniotic pregnancy. Several factors that have been implicated in the aetiology of monozygotic triple pregnancies after IVF appear to be present in this case.

Evidence for frequency-based constituents in the mental lexicon: collocations involving the word of.

In this paper, it is hypothesized that units larger than the traditional word, such as two-word collocations and phrases, may be stored in the mental lexicon and accessed holistically. Following previously published work on the Network or Usage-based model of lexical storage (Bybee, 1985, 1995), we suggest that the mechanism determining this constituency is the frequency with which items occur together in natural, connected speech: the collocational frequency. The present study uses a word-monitoring paradigm to investigate reaction times to the English function word of in collocations of varying levels of frequency.