High Recreational Gamblers Show Increased Stimulatory Effects of an Acute Laboratory Gambling Challenge.

Gambling in moderation is a socially acceptable behavior and over 60% of the Swedish population gambles every year. It has been seen that slot machines are one of the most addictive and problematic forms of gambling and contribute highly to an addictive behavior. It is unclear why some individuals intensify their gambling behavior over time to extreme levels while others do not.

Characterization of the binding site for d-deprenyl in human inflamed synovial membrane.

Aims: d-Deprenyl when used as a positron emission tomography tracer visualizes peripheral inflammation. The major aim of the current study was to identify and investigate the properties of the binding target for d-deprenyl in synovial membrane explants from arthritic patients.

Main Methods: Thirty patients diagnosed with arthritis or osteoarthritis were enrolled into the study.

High-throughput screening and radioligand binding studies reveal monoamine oxidase-B as the primary binding target for d-deprenyl.

Aims: d-deprenyl is a useful positron emission tomography tracer for visualization of inflammatory processes. Studies with [(11)C]-d-deprenyl showed robust uptake in peripheral painful sites of patients with rheumatoid arthritis or chronic whiplash injury. The mechanism of preferential d-deprenyl uptake is not yet known, but the existence of a specific binding site was proposed.

Stress and consumption of alcohol in humans with a Type 1 family history of alcoholism in an experimental laboratory setting.

Background: This paper investigates how stress interacts with alcohol consumption in subjects with a family history of alcoholism. One mechanism for increases in alcohol intake may be that stress alters the subjective effects produced by the drug.

Methods: 58 healthy volunteers, divided into two groups of family history positive (FHP) and two groups of family history negative (FHN) participated in two laboratory sessions, in which they performed in one out of two sessions a stress task.

Bone substitute as an on-lay graft on rat tibia.

Objectives: To investigate the capacity of Cerament, an injectable bone substitute, to guide bone generation from a cortical surface.

Materials And Method: Cerament was applied to the cortical surface of rat tibiae and investigated histologically after 3, 6 and 12 weeks, using a procedure similar to that performed in sham-operated rats.

Results: In both groups, the thickness of the bone cortex increased significantly from 473 + or - 58 microm (mean + or - SD) at day 0 to 1193 + or - 255 microm (Cerament) and 942 + or - 323 microm (sham) after 3 weeks.