CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice.

Dysregulation of hypothalamic ceramides has been associated with disrupted neuronal pathways in control of energy and glucose homeostasis. However, the specific ceramide species promoting neuronal lipotoxicity in obesity have remained obscure. Here, we find increased expression of the C ceramide-producing ceramide synthase (CerS)6 in cultured hypothalamic neurons exposed to palmitate in vitro and in the hypothalamus of obese mice.

The connection between stress, density, and speed in crowds.

Moving around in crowds is part of our daily lives, and we are used to the associated restriction of mobility. Nevertheless, little is known about how individuals experience these limitations. Such knowledge would, however, help to predict behavior, assess crowding, and improve measures for safety and comfort.

Don't stop me now: Psychological effects of interrupting a moving pedestrian crowd and a video game.

Interruptions are a part of our everyday lives. They are inevitable in complex societies, especially when many people move from one place to another as a part of their daily routines. The main aim of this research is to understand the effects of interruptions on individuals from a psychological and crowd dynamics perspective.

Waiting and walking with strangers: a socio-psychological pedestrian experiment on joint action in anonymous situations.

Research on pedestrian dynamics has generally dealt with temporary gatherings of people who do not know each other personally. These gatherings are often framed as highly individualized encounters in which social interactions play no or only a marginal role. However, recent research based on self-categorization theory showed the relevance of salient social identity for crowd dynamics.

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.

The wake-active orexin system plays a central role in the dynamic regulation of glucose homeostasis. Here we show orexin receptor type 1 and 2 are predominantly expressed in dorsal raphe nucleus-dorsal and -ventral, respectively. Serotonergic neurons in ventral median raphe nucleus and raphe pallidus selectively express orexin receptor type 1.

Crowds in front of bottlenecks at entrances from the perspective of physics and social psychology.

This article presents an interdisciplinary study of physical and social psychological effects on crowd dynamics based on a series of bottleneck experiments. Bottlenecks are of particular interest for applications such as crowd management and design of emergency routes because they limit the performance of a facility. In addition to previous work on the dynamics within the bottleneck, this study focuses on the dynamics in front of the bottleneck, more specifically, at entrances.

Histology in 3D: development of an online interactive student resource on epithelium.

Epithelium is an important and highly specialised tissue type that makes up the lining of inner and outer surfaces of the human body. It is proposed that a self-study tool adds to efficient learning and lecturing on this complicated topic in medical curricula. This paper describes the development and evaluation of an online interactive 3D resource on epithelium for undergraduate medical students.

Collective phenomena in crowds-Where pedestrian dynamics need social psychology.

This article is on collective phenomena in pedestrian dynamics during the assembling and dispersal of gatherings. To date pedestrian dynamics have been primarily studied in the natural and engineering sciences. Pedestrians are analyzed and modeled as driven particles revealing self-organizing phenomena and complex transport characteristics.